Evidence map›Paper›PMID 32287146›Full record

Observational studyJournal of glaucoma2020

Disc Hemorrhages Are Associated With the Presence and Progression of Glaucomatous Central Visual Field Defects.

Aakriti G Shukla, Portia E Sirinek, C Gustavo De Moraes, Dana M Blumberg, George A Cioffi, Alon Skaat, Christopher A Girkin, Robert N Weinreb, Linda M Zangwill, Donald C Hood and 1 more

Abstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of glaucoma, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Observational
  9. Macular Optical Coherence Tomography Imaging in Glaucoma.Journal of ophthalmic & vision research
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Aakriti G ShuklaBernard and Shirlee Brown Glaucoma Research Laboratory, Columbia University Medical Center, Edward S. Harkness Eye Institute.
Portia E SirinekBernard and Shirlee Brown Glaucoma Research Laboratory, Columbia University Medical Center, Edward S. Harkness Eye Institute.
C Gustavo De MoraesBernard and Shirlee Brown Glaucoma Research Laboratory, Columbia University Medical Center, Edward S. Harkness Eye Institute.
Dana M BlumbergBernard and Shirlee Brown Glaucoma Research Laboratory, Columbia University Medical Center, Edward S. Harkness Eye Institute.
George A CioffiBernard and Shirlee Brown Glaucoma Research Laboratory, Columbia University Medical Center, Edward S. Harkness Eye Institute.
Alon SkaatGoldschleger Eye Institute, Sheba Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Christopher A GirkinSchool of Medicine, University of Alabama, Birmingham, AL.
Robert N WeinrebHamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California, San Diego, CA.
Linda M ZangwillHamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California, San Diego, CA.
Donald C HoodDepartments of Psychology and Ophthalmology, Columbia University, New York, NY.
Jeffrey M LiebmannBernard and Shirlee Brown Glaucoma Research Laboratory, Columbia University Medical Center, Edward S. Harkness Eye Institute.

Funding

African Descent And Glaucoma Evaluation Study (ADAGES)U10EY014267 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZANGWILL, LINDA M · 2002 to 2010
$13.2M
Vision BiostatisticsP30EY022589 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Derek Stuart Welsbie · 2012 to 2026
$10.3M
Diagnostic Innovations in Glaucoma:Structural AssessmentR01EY011008 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZANGWILL, LINDA M · 1995 to 2015
$8.7M
VISUAL FUNCTION IN GLAUCOMA AND OCULAR HYPERTENSIONR01EY008208 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MEDEIROS, FELIPE · 1990 to 2010
$5.7M
Diagnostic Innovations in Glaucoma Study (DIGS): High Myopia and Advanced DiseaseR01EY027510 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LINDA M ZANGWILL · 2017 to 2026
$5.3M
African Descent and Glaucoma Evaluation (ADAGES) II: Glaucoma ProgressionR01EY019869 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZANGWILL, LINDA M · 2010 to 2014
$2.8M
African Descent and Glaucoma Evaluation (ADAGES) IV: Alterations of the lamina cribrosa in progressionR01EY026574 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI FAZIO, MASSIMO ANTONIO, GIRKIN, CHRISTOPHER ANTHONY · 2017 to 2020
$2.6M
Structural and Functional Progression of Glaucomatous Damage to the MaculaR01EY025253 · NEI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI DE MORAES, CARLOS GUSTAVO · 2015 to 2017
$1.2M
Quantification of Glaucomatous Optic NeuropathyK23EY013959 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GIRKIN, CHRISTOPHER ANTHONY · 2002 to 2006
$994k
NEI NIH HHS K23 EY013959NEI NIH HHS P30 EY022589NEI NIH HHS R01 EY008208NEI NIH HHS R01 EY011008NEI NIH HHS R01 EY019869NEI NIH HHS R01 EY025253NEI NIH HHS R01 EY026574NEI NIH HHS R01 EY027510NEI NIH HHS U10 EY014267
6 · The paper itself

Abstract

precisIn this prospective cohort study, disc hemorrhages were associated with more severe central damage on 24-2 and 10-2 visual fields (VFs), and faster progression globally on 24-2 VFs and centrally on 10-2 VFs. PURPOSE: To study the relationship between disc hemorrhage (DH) and the presence and progression of glaucomatous central VF damage.

methodsCross-sectional and longitudinal analyses were performed on data from the African Descent and Glaucoma Evaluation Study (ADAGES) cohort. Two masked investigators reviewed disc photographs for the presence and location of DH. 24-2 central VF damage was based on the number of test locations within the central 10 degrees of the 24-2 field pattern deviation and their mean total deviation (MTD). 10-2 central VF damage was based on pattern deviation and MTD. Main outcome measures were the association between DH and presence of central VF damage and between DH and worsening of VF.

resultsDH was detected in 21 of 335 eyes (6.2%). In the cross-sectional analysis, DH was significantly associated with more severe central damage on 24-2 [incidence rate ratio=1.47; 95% confidence interval (CI)=1.02-2.12; P=0.035] and 10-2 VFs (incidence rate ratio=1.81; 95% CI=1.26-2.60; P=0.001). In the longitudinal analysis, DH eyes progressed faster than non-DH eyes based on 24-2 global MTD rates (difference in slopes, β=-0.06; 95% CI=-0.11 to -0.01; P=0.009) and 10-2 MTD rates (β=-0.10; 95% CI=-0.14 to -0.06; P< 0.001), but not 24-2 central MTD rates (β=-0.02; 95% CI=-0.078 to 0.026; P=0.338).

conclusionDH was associated with the presence and progression of central VF defects. DH identification should prompt intensive central VF monitoring and surveillance with 10-2 fields to detect progression.

Indexed as

AgedAged, 80 and overCohort StudiesCross-Sectional StudiesDisease ProgressionFemaleGlaucomaHumansIncidenceIntraocular PressureLongitudinal StudiesMaleMiddle AgedOptic DiskOptic Nerve DiseasesRetinal Hemorrhage

Identifiers

PMID32287146
PMCPMC7272303

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.