ArticleNursing research
Protocol to Measure Hair Cortisol in Low Mass Samples From Very Preterm Infants.
Article in Nursing research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 5 citations in OpenAlex.
- Bias in hair cortisol measures for psychological stress: Self vs. professional collection.Psychoneuroendocrinology · 2026Article
- Hair collection protocol in 12-month-old infants.Comprehensive psychoneuroendocrinology · 2024Article
- Hair sampling for cortisol analysis with mother-toddler dyads living in low-income homes.Infant behavior & development · 2020Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundHair cortisol is a measure of chronic or repeated hypothalamic-pituitary-adrenal axis activation in response to physical or psychological stressors. Hair cortisol has been successfully used as a measure of chronic stress in adults and children; however, its use as a valid measure in preterm infants has been limited by challenges in measuring cortisol in the low mass samples collectable from these infants.
objectivesThe purpose of this report is to present a novel protocol for the measurement of hair cortisol in very low mass hair samples.
methodsSmall changes were made to previously published protocols. After washing and pulverizing the hair samples, a double methanol cortisol extraction was performed. Samples were spiked with a known quantity of cortisol and analyzed in duplicate using an enzyme-linked immunosorbent assay.
resultsHair cortisol was detectable in samples weighing between 0.4 and 10.9 mg. The mean cortisol level was 23.74 pg/mg hair (SD = 26.38). DISCUSSION: With small changes to previously published laboratory protocols, cortisol is quantifiable in low mass hair samples from preterm infants. This technical advance is an important step toward quantifying the stress experiences of hospitalized preterm infants.
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