Evidence map›Paper›PMID 32287073›Full record

ArticleAIDS (London, England)2020

Performing rapid autopsy for the interrogation of HIV reservoirs.

Stephen A Rawlings, Laura Layman, Davey Smith, Brianna Scott, Caroline Ignacio, Magali Porrachia, Susanna Concha-Garcia, Steven Hendrickx, Andy Kaytes, Jeff Taylor and 1 more

Abstract read
In one paragraph

Article in AIDS (London, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Intersectionality-Informed HIV Cure-Related Research at the End of Life: A Call to Action.International journal of environmental research and public health · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Stephen A RawlingsDivision of Infectious Diseases and Global Public Health, University of California, San Diego, Stein Clinical Research Building.
Laura LaymanDivision of Infectious Diseases and Global Public Health, University of California, San Diego, Stein Clinical Research Building.
Davey SmithDivision of Infectious Diseases and Global Public Health, University of California, San Diego, Stein Clinical Research Building.
Brianna ScottDivision of Infectious Diseases and Global Public Health, University of California, San Diego, Stein Clinical Research Building.
Caroline IgnacioDivision of Infectious Diseases and Global Public Health, University of California, San Diego, Stein Clinical Research Building.
Magali PorrachiaVeterans Affairs Viral Research Laboratory.
Susanna Concha-GarciaDivision of Infectious Diseases and Global Public Health, University of California, San Diego, Stein Clinical Research Building.
Steven HendrickxDivision of Infectious Diseases and Global Public Health, University of California, San Diego, Stein Clinical Research Building.
Andy KaytesAntiviral Research Center Community Advisory Board, University of California, San Diego, San Diego.
Jeff TaylorAntiviral Research Center Community Advisory Board, University of California, San Diego, San Diego.
Sara GianellaDivision of Infectious Diseases and Global Public Health, University of California, San Diego, Stein Clinical Research Building.

Funding

UC San Diego Clinical and Translational Research InstituteUL1TR001442 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S, HOGARTH, MICHAEL · 2015 to 2024
$88.3M
VirologyP30AI036214 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Maile Ann Young Karris · 1994 to 2026
$78.4M
HOPE Training GrantT32AI007384 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Sara Gianella Weibel, Scott L Letendre · 1990 to 2026
$9.7M
Revealing Reservoirs during Rebound (R3)P01AI131385 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DEGRUTTOLA, VICTOR GERARD · 2017 to 2021
$8.7M
Effect of Declining Sex Hormones on HIV persistence in HIV Infected Women on ARTR21HD094646 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GIANELLA WEIBEL, SARA · 2017 to 2018
$441k
NCATS NIH HHS UL1 TR001442NIAID NIH HHS P01 AI131385NIAID NIH HHS P30 AI036214NIAID NIH HHS T32 AI007384NICHD NIH HHS R21 HD094646
6 · The paper itself

Abstract

: Rapid autopsy at the end of life in people with HIV (PWH) permits the preservation of valuable tissue specimens for subsequent study of HIV reservoirs. At our institution, we have developed a cohort of PWH who consent to a rapid autopsy to gather a wide range of fluids and tissues with the goal of advancing HIV cure research. The protocol for successfully performing these autopsies has required careful thought and development over months and years. We have now successfully performed six rapid autopsies and detail here our steps to build the study cohort, train and staff a team of more than a dozen personnel, and process and preserve hundreds of samples from each autopsy.

Indexed as

Forensic PathologyAltruismAutopsyCohort StudiesHIV InfectionsHumansTissue and Organ Procurement

Identifiers

PMID32287073
PMCPMC7780881

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.