ArticleScientific reports2020
Delayed application of silver nanoparticles reveals the role of early inflammation in burn wound healing.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The trial behind it
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Who cites it
28 citing papers in PubMed, 89 citations in OpenAlex.
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- MXene quantum dot polymer nanocomposites as smart platforms for targeted drug delivery and multifunctional biomedical applications: an updated review.Discover nano · 2026Review
- Burn Infections and Sepsis: Challenges and Future Prospects of Antibacterial Therapy.Antibiotics (Basel, Switzerland) · 2026Review
- pH-responsive bilayer hydrogel with sequential release of morin-based nanoparticles and bFGF for the treatment of the "ice and fire" wounds.Materials today. Bio · 2025Article
- Nanoparticle-based approaches for wound healing: a comprehensive review of nanomaterials enhancing tissue regeneration.Discover nano · 2025Review
- Silver Nanoparticle-Silk Protein Nanocomposites: A Synergistic Biomimetic Approach for Advanced Antimicrobial Applications.Biomimetics (Basel, Switzerland) · 2025Review
- Preparation of Allium cepa-derived exosome-like nanovesicles and their anti-inflammatory potential in a skin wound healing mouse model.Molecular biology reports · 2025Article
- Biosynthesis of silver nanoparticles by Talaromyces funiculosus for therapeutic applications and safety evaluation.Scientific reports · 2025Article
- Delayed Immune Response Upon Injury in Diabetic Wounds Impedes Healing.Immunity, inflammation and disease · 2025Article
- Modification of Ti13Nb13Zr Alloy Surface via Plasma Electrolytic Oxidation and Silver Nanoparticles Decorating.Materials (Basel, Switzerland) · 2025Article
- Enhancing Wound Healing with Nanohydrogel-Entrapped Plant Extracts and Nanosilver: An In Vitro Investigation.Molecules (Basel, Switzerland) · 2024Article
- Silver Nanoparticles in Therapeutics and Beyond: A Review of Mechanism Insights and Applications.Nanomaterials (Basel, Switzerland) · 2024Review
- Wound Healing Promotion via Release of Therapeutic Metallic Ions from Phosphate Glass Fibers: AnACS applied materials & interfaces · 2024Article
- Regulation of inflammation during wound healing: the function of mesenchymal stem cells and strategies for therapeutic enhancement.Frontiers in pharmacology · 2024Review
- A Microfluidic Approach for Synthesis of Silver Nanoparticles as a Potential Antimicrobial Agent in Alginate-Hyaluronic Acid-Based Wound Dressings.International journal of molecular sciences · 2023Article
- Antibacterial Thermosensitive Silver-Hydrogel Nanocomposite Improves Wound Healing.Gels (Basel, Switzerland) · 2023Article
- Antibacterial coatings on orthopedic implants.Materials today. Bio · 2023Review
- PluronicGels (Basel, Switzerland) · 2023Article
- 3D Printing as a Technological Strategy for the Personalized Treatment of Wound Healing.AAPS PharmSciTech · 2023Review
- Structural parameters of nanoparticles affecting their toxicity for biomedical applications: a review.Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology · 2023Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Burn injury is common, and antimicrobial agents are often applied immediately to prevent wound infection and excessive inflammatory response. Although inflammation is essential for clearing bacteria and creating an environment conducive to the healing process, it is unclear what time-frame inflammation should be present for optimal wound healing. This study critically investigated the role of early inflammation in burn wound healing, and also revealed the molecular mechanisms underlying the pro-healing effects of silver nanoparticles (AgNPs). We created a burn injury mouse model using wild-type and Smad3-/- mice, which were topically treated with AgNPs at different post-burn days, and examined the healing processes of the various groups. We also delineated the molecular pathways underlying the anti-inflammation and pro-healing effects of AgNPs by morphological and histological analysis, immuno-histochemistry, and western blotting. Our results showed that (1) AgNPs regulated pro-inflammatory cytokine IL-6 production of keratinocytes and neutrophils infiltration through KGF-2/p38 signaling pathway, (2) Topical AgNPs treatment immediately after burn injury significantly supressed early inflammation but resulted in delayed healing, (3) A short delay in AgNPs application (post-burn day 3 in our model) allowed early inflammation in a controlled manner, and led to optimal burn wound healing. Thus, our current study showed that some degree of early inflammation was beneficial, but prolonged inflammation was detrimental for burn wound healing. Further evaluation and clinical translation of this finding is warranted.
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Registered trials
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