ArticleScientific reports2020
Preoperative Serum Fibrinogen is Associated With Acute Kidney Injury after Cardiac Valve Replacement Surgery.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 12 citations in OpenAlex.
- Article
- Predicting Major Adverse Cardiovascular Events After Cardiac Surgery Using Combined Clinical, Laboratory, and Echocardiographic Parameters: A Machine Learning Approach.Medicina (Kaunas, Lithuania) · 2025Article
- Prognostic significance of fibrinogen levels in sepsis-associated acute kidney injury: unveiling a nonlinear relationship and clinical implications.Frontiers in nephrology · 2024Article
- Low preoperative serum fibrinogen level is associated with postoperative acute kidney injury in patients with in acute aortic dissection.Journal of cardiothoracic surgery · 2023Article
- Fibrinogen and antithrombin III are associated with in-hospital mortality among critically ill patients with acute kidney injury.Renal failure · 2022Article
- Predictive Value of the Transthoracic Echocardiography Index for Acute Kidney Injury after Cardiac Valve Surgery.Journal of cardiovascular development and disease · 2022Article
- Prognostic value of fibrinogen to albumin ratios among critically ill patients with acute kidney injury.Internal and emergency medicine · 2022Article
- Predictive utility of fibrinogen in acute kidney injury in living donor liver transplantation: A propensity score-matching analysis.PloS one · 2021Article
- Novel Plasma Biomarker-Based Model for Predicting Acute Kidney Injury After Cardiac Surgery: A Case Control Study.Frontiers in medicine · 2021Article
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute kidney injury (AKI) after open cardiac surgery is associated with a longer hospital stay and higher risk of mortality. We aimed to explore the association between preoperative serum fibrinogen level and risk of postoperative AKI in patients with open cardiac surgery. 3459 patients who underwent cardiac valve replacement surgery from January 2011 to September 2015 were recruited. The primary outcome was AKI, defined as AKI stage-1 or higher based on the Kidney Disease: Improving Global Outcomes (KDIGO) Guidelines. Synthetic Minority Oversampling Technique (SMOTE) was used to subsample minority groups to eliminate classification bias. 510 (14.74%) patients developed postoperative AKI. Serum fibrinogen was independently associated with AKI (OR = 1.211, 95% CI 1.080 to 1.358, p = 0.001) after adjustment of covariates. The receiver operator characteristic (ROC) curve for the outcome of AKI, after the addition of serum fibrinogen, had a c-statistic increasing from 0.72 to 0.73 (p < 0.001). This translated to a substantially improved AKI risk classification with a net reclassification index of 0.178 (p < 0.001). After SMOTE subsampling, serum fibrinogen was still independently associated with AKI grade 1 or higher (OR = 1.212, 95% CI 1.1089 to 1.347, p = 0.003). Preoperative serum fibrinogen levels were associated with the risk of postoperative AKI after cardiac valve replacement surgery.
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