ArticleScientific reports2020
Sex differences in auditory fear discrimination are associated with altered medial prefrontal cortex function.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 30 citations in OpenAlex.
- A novel finding on sex-dependent diverse behavioral responses to the anticipation of a threat in a rat model of fear conditioning with the involvement of brain-derived neurotrophic factor (BDNF) in the prefrontal cortex.Learning & behavior · 2026Article
- A Selective Cortico-Limbic Network Organizes Behavior During Reward Seeking Under Threat.Journal of neuroscience research · 2026Article
- A novel role for the infralimbic cortex in conditioned fear responding.Oxford open neuroscience · 2026Article
- Sex-specific exploration accounts for differences in valence learning in male and female mice.eLife · 2025Article
- Adolescent male and female rats show enhanced latent inhibition of conditioned fear compared to adult rats.Frontiers in behavioral neuroscience · 2025Article
- An infralimbic cortex neuronal ensemble encoded during learning attenuates fear generalization expression.bioRxiv : the preprint server for biology · 2024Article
- Sex differences in contextual fear expression are associated with altered medial prefrontal cortex activity.bioRxiv : the preprint server for biology · 2024Article
- Sex divergent behavioral responses in platform-mediated avoidance and glucocorticoid receptor blockade.Psychoneuroendocrinology · 2024Article
- Dopamine D1-like receptors modulate synchronized oscillations in the hippocampal-prefrontal-amygdala circuit in contextual fear.Scientific reports · 2023Article
- New perspectives on sex differences in learning and memory.Trends in endocrinology and metabolism: TEM · 2023Review
- Persistent disruption of overexpectation learning after inactivation of the lateral orbitofrontal cortex in male rats.Psychopharmacology · 2023Article
- Patterns of Arc mRNA expression in the rat brain following dual recall of fear- and reward-based socially acquired information.Scientific reports · 2023Article
- Sex differences in fear responses: Neural circuits.Neuropharmacology · 2023Review
- Stress and sex-dependent effects on conditioned inhibition of fear.Learning & memory (Cold Spring Harbor, N.Y.) · 2022Article
- Assessing the importance of sex in a hippocampus-dependent behavioral test battery in C57BL/6NTac mice.Learning & memory (Cold Spring Harbor, N.Y.) · 2022Article
- Sex differences in neuronal systems function and behaviour: beyond a single diagnosis in autism spectrum disorders.Translational psychiatry · 2021Review
- Neural correlates of safety learning.Behavioural brain research · 2021Article
- Sex Differences in the Development of the Rodent Corticolimbic System.Frontiers in neuroscience · 2020Review
- Sex Differences in BNST and Amygdala Activation by Contextual, Cued, and Unpredictable Threats.eNeuroArticle
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
The increased prevalence of post-traumatic stress disorder (PTSD) that is observed in women may involve sex differences in learned fear inhibition and medial prefrontal cortex (mPFC) function. PTSD is characterized by fear overgeneralization involving impaired fear regulation by safety signals. We recently found that males show fear discrimination and females show fear generalization involving reduced safety signalling after extended fear discrimination training. Here we determined if these sex differences involve altered mPFC function. Male and female rats underwent three days of auditory fear discrimination training, where one tone (CS+) was paired with footshock and another tone (CS-) was presented alone. Local field potentials were recorded from prelimbic (PL) and infralimbic (IL) mPFC during retrieval. We found that males discriminated and females generalized based on cue-induced freezing at retrieval. This was accompanied by sex differences in basal theta and gamma oscillations in PL and IL. Importantly, males also showed PL/IL theta activation during safety signalling by the CS- and IL gamma activation in response to the threat-related CS+, both of which were absent in females. These results add to growing evidence indicating that sex differences in learned fear inhibition are associated with altered mPFC function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.