Evidence map›Paper›PMID 32286456›Full record

ArticleScientific reports2020

Prolactin Acts on Myeloid Progenitors to Modulate SMAD7 Expression and Enhance Hematopoietic Stem Cell Differentiation into the NK Cell Lineage.

Dejene M Tufa, Tyler Shank, Ashley M Yingst, George Devon Trahan, Seonhui Shim, Jessica Lake, Renee Woods, Kenneth Jones, Michael R Verneris

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
  4. Review
  5. Prolactin: The Third Hormone in Breast Cancer.Frontiers in endocrinology · 2022
    Review
  6. Review
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Dejene M TufaUniversity of Colorado and Children's Hospital of Colorado, Department of Pediatrics, Center for Cancer and Blood Disorders. Research Complex 1, North Tower, 12800 E. 19th Ave., Mail Stop 8302, Room P18-4108, Aurora, CO, 80045, USA.
Tyler ShankUniversity of Colorado and Children's Hospital of Colorado, Department of Pediatrics, Center for Cancer and Blood Disorders. Research Complex 1, North Tower, 12800 E. 19th Ave., Mail Stop 8302, Room P18-4108, Aurora, CO, 80045, USA.
Ashley M YingstUniversity of Colorado and Children's Hospital of Colorado, Department of Pediatrics, Center for Cancer and Blood Disorders. Research Complex 1, North Tower, 12800 E. 19th Ave., Mail Stop 8302, Room P18-4108, Aurora, CO, 80045, USA.
George Devon TrahanUniversity of Colorado and Children's Hospital of Colorado, Department of Pediatrics, Center for Cancer and Blood Disorders. Research Complex 1, North Tower, 12800 E. 19th Ave., Mail Stop 8302, Room P18-4108, Aurora, CO, 80045, USA.
Seonhui ShimUniversity of Colorado and Children's Hospital of Colorado, Department of Pediatrics, Center for Cancer and Blood Disorders. Research Complex 1, North Tower, 12800 E. 19th Ave., Mail Stop 8302, Room P18-4108, Aurora, CO, 80045, USA.
Jessica LakeUniversity of Colorado and Children's Hospital of Colorado, Department of Pediatrics, Center for Cancer and Blood Disorders. Research Complex 1, North Tower, 12800 E. 19th Ave., Mail Stop 8302, Room P18-4108, Aurora, CO, 80045, USA.
Renee WoodsUniversity of Colorado and Children's Hospital of Colorado, Department of Pediatrics, Center for Cancer and Blood Disorders. Research Complex 1, North Tower, 12800 E. 19th Ave., Mail Stop 8302, Room P18-4108, Aurora, CO, 80045, USA.
Kenneth JonesUniversity of Colorado and Children's Hospital of Colorado, Department of Pediatrics, Center for Cancer and Blood Disorders. Research Complex 1, North Tower, 12800 E. 19th Ave., Mail Stop 8302, Room P18-4108, Aurora, CO, 80045, USA.
Michael R VernerisUniversity of Colorado and Children's Hospital of Colorado, Department of Pediatrics, Center for Cancer and Blood Disorders. Research Complex 1, North Tower, 12800 E. 19th Ave., Mail Stop 8302, Room P18-4108, Aurora, CO, 80045, USA. Michael.Verneris@CUAnschutz.edu.
Center for Cancer and Blood Disorders · US

Funding

Lymphoid Tissue Inducer/NK22 Cells and Post-transplant Immune RecoveryR01AI100879 · NIAID · UNIVERSITY OF MINNESOTA · PI VERNERIS, MICHAEL R. · 2013 to 2017
$1.9M
NIAID NIH HHS R01 AI100879
6 · The paper itself

Abstract

Numerous cell types modulate hematopoiesis through soluble and membrane bound molecules. Whether developing hematopoietic progenitors of a particular lineage modulate the differentiation of other hematopoietic lineages is largely unknown. Here we aimed to investigate the influence of myeloid progenitors on CD34

Indexed as

Antigens, CD34CD56 AntigenCell DifferentiationCell Lineagefms-Like Tyrosine Kinase 3Gene Expression Regulation, DevelopmentalHematopoiesisHematopoietic Stem CellsHumansKiller Cells, NaturalLymphocytesLymphopoiesisMyeloid Progenitor CellsProlactinReceptors, ProlactinSmad7 ProteinAntigens, CD34CD56 AntigenFLT3 protein, humanfms-Like Tyrosine Kinase 3ProlactinReceptors, ProlactinSmad7 ProteinTransforming Growth Factor beta1

Identifiers

PMID32286456
PMCPMC7156717
OpenAlexW3015373549

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.