ArticleScientific reports2020
Spirulina platensis prevents oxidative stress and inflammation promoted by strength training in rats: dose-response relation study.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.
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Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 71 citations in OpenAlex.
- Pharmacological insights intoFrontiers in pharmacology · 2025Pooled it
- Antioxidant, anti-inflammatory and immunomodulatory effects of spirulina in exercise and sport: A systematic review.Frontiers in nutrition · 2022Pooled it
- Effect ofNutrients · 2024Trial
- The Combinatory Effect of Spirulina Supplementation and Resistance Exercise on Plasma Contents of Adipolin, Apelin, Ghrelin, and Glucose in Overweight and Obese Men.Mediators of inflammation · 2022Trial
- The Effects of Spirulina Supplementation on Redox Status and Performance Following a Muscle Damaging Protocol.International journal of molecular sciences · 2021Trial
- Review
- The protective effects of Spirulina platensis hydromethanolic extract against deoxycorticosterone acetate-salt-induced spontaneously hypertensive rats.Open veterinary journal · 2026Article
- The Beneficial Effects of Marine Plant-Derived Compounds on the Musculoskeletal System.International journal of molecular sciences · 2026Review
- Article
- Spirulina as a natural shield: a comprehensive review of its protective effects against lead toxicity.Archives of toxicology · 2025Review
- Effect ofMedical sciences (Basel, Switzerland) · 2025Article
- Anti-Inflammatory effects of Lactobacillus helveticus and Arthrospira platensis on colonic cells inflamed by Crohn's disease-associated Escherichia coli.BMC molecular and cell biology · 2025Article
- C-Phycocyanin Extract Modulates Thermogenic and Inflammatory Markers in Brown Adipose Tissue of High-Fat Diet-Fed Animals.Molecules (Basel, Switzerland) · 2025Article
- Microalgae and exercise: from molecular mechanisms and brain health to clinical perspectives in the context of 3P medicine.The EPMA journal · 2025Review
- Effects of Spirulina Supplementation on C-Reactive Protein (CRP): A Systematic Review and Dose-Response Meta-Analysis.Food science & nutrition · 2025Review
- Fueling immunity: the synergy of natural products and exercise for optimal health.Frontiers in pharmacology · 2025Review
- High-intensity interval training, but not Spirulina supplementation, changes muscle regeneration signaling proteins in aged rats with obesity and diabetes.European journal of translational myology · 2024Article
- Phycocyanin-Loaded Alginate-Based Hydrogel Synthesis and Characterization.Marine drugs · 2024Article
- Effects of a Dietary Microalgae (Nutrients · 2024Observational
- Repro-protective activity of amygdalin and spirulina platensis in niosomes and conventional forms against aluminum chloride-induced testicular challenge in adult rats: role of CYP11A1, StAR, and HSD-3B expressions.Naunyn-Schmiedeberg's archives of pharmacology · 2024Article
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Authors and funding
13 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purpose of this study was to evaluate the effects of Spirulina Platensis supplementation on selected blood markers of oxidative stress, muscle damage, inflammation, and performance in trained rats. Rats (250 g - 300 g) were submitted to a strength training program (eight weeks), divided into four groups: control (GT) (trained without supplementation), trained with daily-supplementation of 50 mg/kg (GT50), 150 mg/kg (GT150) and 500 mg/kg (GT500). Training consisted of a jump protocol in PVC-cylinder containing water, with increasing load over experimental weeks. We evaluated the markers of oxidative stress (malondialdehyde - MDA and antioxidant capacity) and inflammation (C-reactive protein) at the end of the training. Among groups submitted to strength training, concentration of C-reactive protein decreased after 8 weeks of intervention in the trained group and GT500. Strength training enhanced plasma MDA concentration of malondialdehyde with supplementation of S. platensis in GT150 and GT500. In plasma analysis, strength training enhanced the percentage of oxidation inhibition, with spirulina supplementation in rates of 150 and 500 mg/kg. Spirulina supplementation for 8 weeks (in a dose-effect manner) improved antioxidant capacity as well as attenuated exercise-induced increases in ROS and inflammation. As a practical application, the use as high doses did not cause a reduction in positive physiological adaptations to exercise training. Additional studies are necessary to test the application of Spirulina Platensis in other contexts, as collective sports (basketball, football, soccer).
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