ArticleScientific reports2020
The association between second to fourth digit ratio, reproductive and general health among women: findings from an Israeli pregnancy cohort.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Social Determinants of Health and Dysmenorrhea: A Systematic Review.The journal of pain · 2024Pooled it
- Is There a Correlation between the Second-to-Four Digit Ratio (2D:4D) and Endometriosis? Results of a Case-Control Study.Journal of clinical medicine · 2023Article
- Can Digit Ratio (2D:4D) Be Indicative of Predispositions to Autoimmune Thyroid Diseases in Women - Hashimoto Thyroiditis and Graves' Disease?Frontiers in endocrinology · 2022Article
- Thyroid diseases and second to fourth digit ratio in Polish adults.Scientific reports · 2021Article
- Endometriosis and polycystic ovary syndrome are diametric disorders.Evolutionary applications · 2021Review
- Second to fourth (2D:4D) digit ratio and their relationships among a mother and child population in Ghana.Scientific reports · 2021Article
- Variation among human populations in endometriosis and PCOS A test of the inverse comorbidity model.Evolution, medicine, and public health · 2021Review
- The evolutionary biology of endometriosis.Evolution, medicine, and public health · 2021Review
- Second to fourth digit ratio (2D:4D) is associated with dementia in women.Early human development · 2020Article
- Evaluation of Body Fat Composition and Digit Ratio (2D:4D) in Polycystic Ovary Syndrome in Adolescents.Current health sciences journalArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ratio between the length of second and fourth digits (2D:4D) is a putative biomarker for prenatal testosterone and estrogen exposure. The aim of the study was to examine the association between 2D:4D and women's general and reproductive health. This analysis was conducted within a prospective pregnancy cohort study. The study population included 187 women. 2D:4D was measured directly in both hands using a digital caliper. Multivariable linear and logistic models were used to study the associations between digit ratio and the studied health characteristics. Mean age of the participants was 30.7 ± 4.9 years. The mean age at menarche was 12.9 ± 1.4 years. Right hand 2D:4D mean ± SD was 0.965 ± 0.03. Left hand 2D:4D mean ± SD was 0.956 ± 0.03. An association was found between right 2D:4D and age at menarche, with older age in women with 2D:4D ≥ mean versus 2D:4D < mean (13.2 ± 1.5 and 12.8 ± 1.3 respectively, b = 0.48, 95%CI:0.06-0.91) while controlling for ethnicity. Higher 2D:4D was also associated with heavier menses bleeding and dysmenorrhea. There is an association between 2D:4D and sub optimal reproductive characteristics, including later age at menarche, heavier menses bleeding and dysmenorrhea. These findings support the association between the intrauterine period and reproductive characteristics. Further studies are required to support our findings.
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