Evidence map›Paper›PMID 32286321›Full record

ArticleNature communications2020

Structural insights into the mechanism and inhibition of transglutaminase-induced ubiquitination by the Legionella effector MavC.

Yajuan Mu, Yue Wang, Yanfei Huang, Dong Li, Youyou Han, Min Chang, Jiaqi Fu, Yongchao Xie, Jie Ren, Hao Wang and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.8field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. An expanded lexicon for the ubiquitin code.Nature reviews. Molecular cell biology · 2023
    Review
  7. Review
  8. mLife · 2022
    Article
  9. Review
  10. Article
  11. ThemBio · 2021
    Article
  12. Review
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Yajuan Mu *Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing Key Laboratory of Bioprocess, State Key Laboratory of Chemical Resource Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, 100029, Beijing, China.
Yue Wang *Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing Key Laboratory of Bioprocess, State Key Laboratory of Chemical Resource Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, 100029, Beijing, China.ORCID http://orcid.org/0000-0001-6946-2666
Yanfei Huang *Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing Key Laboratory of Bioprocess, State Key Laboratory of Chemical Resource Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, 100029, Beijing, China.
Dong Li *Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing Key Laboratory of Bioprocess, State Key Laboratory of Chemical Resource Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, 100029, Beijing, China.
Youyou HanBeijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing Key Laboratory of Bioprocess, State Key Laboratory of Chemical Resource Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, 100029, Beijing, China.
Min ChangBeijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing Key Laboratory of Bioprocess, State Key Laboratory of Chemical Resource Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, 100029, Beijing, China.
Jiaqi FuPurdue Institute for Inflammation, Immunology and Infectious Disease and Department of Biological Sciences, Purdue University, West Lafayette, IN, USA.
Yongchao XieBeijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing Key Laboratory of Bioprocess, State Key Laboratory of Chemical Resource Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, 100029, Beijing, China.
Jie RenState Key Laboratory for Biology of Plant Diseases and Insect Pests/Key Laboratory of Control of Biological Hazard Factors (Plant Origin) for Agri-product Quality and Safety, Ministry of Agriculture, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, 100081, Beijing, China.
Hao WangBeijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing Key Laboratory of Bioprocess, State Key Laboratory of Chemical Resource Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, 100029, Beijing, China.
Yi ZhangBeijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing Key Laboratory of Bioprocess, State Key Laboratory of Chemical Resource Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, 100029, Beijing, China.
Zhao-Qing LuoPurdue Institute for Inflammation, Immunology and Infectious Disease and Department of Biological Sciences, Purdue University, West Lafayette, IN, USA.ORCID http://orcid.org/0000-0001-8890-6621
Yue FengBeijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing Key Laboratory of Bioprocess, State Key Laboratory of Chemical Resource Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, 100029, Beijing, China. fengyue@mail.buct.edu.cn.ORCID http://orcid.org/0000-0002-1576-1385
Beijing University of Chemical Technology · CNPurdue University West Lafayette · USInstitute of Plant Protection · CN

Funding

Mechanism of atypical ubiquitination and deubiquitination by bacterial effectorsR01GM126296 · NIGMS · PURDUE UNIVERSITY · PI Chittaranjan Das · 2018 to 2026
$3.6M
Effector-mediated Ubiquitin Manipulation in Legionella Pneumophila PathogenesisR01AI127465 · NIAID · PURDUE UNIVERSITY · PI Qing Deng · 2017 to 2026
$3.4M
NIAID NIH HHS R01 AI127465NIGMS NIH HHS R01 GM126296
6 · The paper itself

Abstract

Protein ubiquitination is one of the most prevalent post-translational modifications, controlling virtually every process in eukaryotic cells. Recently, the Legionella effector MavC was found to mediate a unique ubiquitination through transglutamination, linking ubiquitin (Ub) to UBE2N through Ub

Indexed as

Crystallography, X-RayDeubiquitinating EnzymesDNA, ComplementaryHumansLegionellaProtein Structure, SecondaryTransglutaminasesUbiquitinationDeubiquitinating EnzymesDNA, ComplementaryTransglutaminases

Identifiers

PMID32286321
PMCPMC7156659
OpenAlexW3014983103

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.