ArticleNature communications2020
Interplay between midbrain and dorsal anterior cingulate regions arbitrates lingering reward effects on memory encoding.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed.
- Severe PTSD symptoms magnify episodic memory-encoding deficits and amygdala-ACC attenuation during unpredictable threat in male combat veterans.Molecular psychiatry · 2026Article
- The Brain Endocannabinoid System is Differentially Regulated in Male and Female Patients with First-Episode Psychosis.Schizophrenia bulletin · 2026Article
- The neural substrates responsible for reward sensitivity association with delay discounting: left dorsal anterior cingulate cortex connectivity with right precuneus.Brain structure & function · 2025Article
- Partner-seeking and limbic dopamine system are enhanced following social loss in male prairie voles (Microtus ochrogaster).Genes, brain, and behavior · 2023Article
- Irrelevant Threats Linger and Affect Behavior in High Anxiety.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Hippocampal convergence during anticipatory midbrain activation promotes subsequent memory formation.Nature communications · 2022Article
- Neural basis of associative learning in Trichotillomania and skin-picking disorder.Behavioural brain research · 2022Article
- Average reward rates enable motivational transfer across independent reinforcement learning tasks.Frontiers in behavioral neuroscience · 2022Article
- Signed Reward Prediction Errors in the Ventral Striatum Drive Episodic Memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Reward anticipation selectively boosts encoding of gist for visual objects.Scientific reports · 2020Article
- Dopamine Receptor Subtypes, Physiology and Pharmacology: New Ligands and Concepts in Schizophrenia.Frontiers in pharmacology · 2020Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rewarding events enhance memory encoding via dopaminergic influences on hippocampal plasticity. Phasic dopamine release depends on immediate reward magnitude, but presumably also on tonic dopamine levels, which may vary as a function of the average accumulation of reward over time. Using model-based fMRI in combination with a novel associative memory task, we show that immediate reward magnitude exerts a monotonically increasing influence on the nucleus accumbens, ventral tegmental area (VTA), and hippocampal activity during encoding, and enhances memory. By contrast, average reward levels modulate feedback-related responses in the VTA and hippocampus in a non-linear (inverted U-shape) fashion, with similar effects on memory performance. Additionally, the dorsal anterior cingulate cortex (dACC) monotonically tracks average reward levels, while VTA-dACC functional connectivity is non-linearly modulated (inverted U-shape) by average reward. We propose that the dACC computes the net behavioral impact of average reward and relays this information to memory circuitry via the VTA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.