Evidence map›Paper›PMID 32286184›Full record

ArticleViral immunology2020

Interplay of Cyclic GMP-AMP Synthase/Stimulator of IFN Genes and Toll-Like Receptor Nucleic Acid Sensing Pathways in Autoinflammation and Abnormal Bone Formation due to DNaseII-Deficiency.

Ann Marshak-Rothstein, Catherine A Manning, Rebecca Baum, Sudesh Pawaria, Ellen M Gravallese

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viral immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Ann Marshak-RothsteinDivision of Rheumatology, University of Massachusetts Medical School, Worcester, Massachusetts.
Catherine A ManningDivision of Rheumatology, University of Massachusetts Medical School, Worcester, Massachusetts.
Rebecca BaumDivision of Rheumatology, University of Massachusetts Medical School, Worcester, Massachusetts.
Sudesh PawariaDivision of Rheumatology, University of Massachusetts Medical School, Worcester, Massachusetts.
Ellen M GravalleseDivision of Rheumatology, University of Massachusetts Medical School, Worcester, Massachusetts.
University of Massachusetts Chan Medical School · US

Funding

Toll-Like Receptors in Systemic Autoimmune DiseaseP01AR050256 · NIAMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SHLOMCHIK, MARK J · 2004 to 2013
$13.4M
Regulation of Lupus by Cytosolic DNA SensorsR01AI128358 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI FITZGERALD, KATHERINE A., MARSHAK-ROTHSTEIN, ANN · 2017 to 2021
$2.7M
Distinct Functional Outcomes of BCR/TLR7 and BCR/TLR9 Co-engagementR01AR066808 · NIAMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI MARSHAK-ROTHSTEIN, ANN · 2015 to 2019
$2.6M
Innate Immunity Training ProgramT32AI095213 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SILVERMAN, NEAL · 2011 to 2025
$2.5M
NIAID NIH HHS R01 AI128358NIAID NIH HHS T32 AI095213NIAMS NIH HHS P01 AR050256NIAMS NIH HHS R01 AR066808
6 · The paper itself

Abstract

Nucleic acid (NA) sensing receptors were first described in the context of host defense. We now know that some endosomal NA sensors play a critical role in the development of systemic autoimmune diseases such as systemic lupus erythematosus, whereas cytosolic Cyclic GMP-AMP Synthase/Stimulator of IFN Genes (cGAS/STING) DNA-detecting pathway has been associated with monogenic autoinflammatory interferonopathies such as Aicardi-Goutieres and Education; collaboration; communication STING-associated vasculopathy with onset in infancy (SAVI). DNaseII hypomorphic patients and DNase

Indexed as

OsteogenesisSignal TransductionAnimalsEndodeoxyribonucleasesFemaleInflammationInterferonsMembrane ProteinsMembrane Transport ProteinsMiceMice, KnockoutNucleic AcidsSTING ProteinToll-Like Receptorsdeoxyribonuclease IIEndodeoxyribonucleasesInterferonsMembrane ProteinsMembrane Transport ProteinsNucleic AcidsSting1 protein, mouseSTING ProteinToll-Like ReceptorsUNC93B1 protein, mouseautoinflammationbone formationDNaseII-deficiencyNA sensorsSTINGUnc93B1

Identifiers

PMID32286184
PMCPMC7185368
OpenAlexW3015482957

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.