ArticleJournal of dental research2020
Nonsteroidal Anti-Inflammatory Drugs and Opioids in Postsurgical Dental Pain.
Article in Journal of dental research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04694300 (Demonstration of OTC Naproxen Sodium's), which is not on this map. Cited by 44 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Demonstration of OTC Naproxen Sodium's (Aleve's) Anti-inflammatory Action in Dental Implant Surgery Patients
Who cites it
44 citing papers in PubMed, 6 syntheses or guidelines pooled it, 102 citations in OpenAlex.
- Perioperative Anti-inflammatory Drugs and Recovery after Periodontal Surgery: A Systematic Review and Meta-Analysis.JDR clinical and translational research · 2026Pooled it
- Cyclooxygenase-2 selective inhibitors increase the risk of alveolar osteitis: A systematic review and meta-analysis.Medicina oral, patologia oral y cirugia bucal · 2026Pooled it
- Evidence-based clinical practice guidelines for the management of acute dental pain.The American journal of emergency medicine · 2025Guideline
- Evidence-based clinical practice guideline for the pharmacologic management of acute dental pain in adolescents, adults, and older adults: A report from the American Dental Association Science and Research Institute, the University of Pittsburgh, and the University of Pennsylvania.Journal of the American Dental Association (1939) · 2024Guideline
- Efficacy of submucosal administration of tramadol on acute pain following third molar surgery: a systematic review and meta-analysis.Frontiers in oral health · 2024Pooled it
- Acute Postoperative Pain Due to Dental Extraction in the Adult Population: A Systematic Review and Network Meta-analysis.Journal of dental research · 2023Pooled it
- Comparative Analgesic Efficacy of Diclofenac and Ketoprofen Transdermal Patches Versus Ibuprofen Tablets for Pain Control After Initial Archwire Placement in Orthodontic Patients: A Randomized Clinical Trial.Pain research & management · 2026Trial
- Analgesic efficacy of meloxicam vs ibuprofen on pain after third molar surgery in adult patients. A randomized controlled clinical trial.Medicina oral, patologia oral y cirugia bucal · 2026Trial
- Effect of different administration methods of dexamethasone on postoperative pain and swelling following implant flap surgery: A randomized controlled trial of patient-centered outcomes.BMC oral health · 2025Trial
- A prospective split-mouth clinical study: comparison of the effect of lornoxicam and etodolac on postoperative sequels following lower third molar surgery.Oral and maxillofacial surgery · 2024Trial
- Comparison of the effects of submucosal hyaluronidase and dexamethasone on postoperative edema, pain, trismus, and infection following impacted third molar surgery.BMC oral health · 2024Trial
- Efficacy and safety of ibuprofen gargle for postoperative pain after mandibular third molar extraction: A phase II, placebo-controlled, double-blind, randomized crossover trial.Clinical and experimental dental research · 2023Trial
- De-Implementing Opioids for Dental Extractions (DIODE): a multi-clinic, cluster-randomized trial of clinical decision support strategies in dentistry.Implementation science : IS · 2023Trial
- Oral and Maxillofacial Surgeon Accuracy in Anticipating Supplemental Opioid Use Following Third Molar Extraction.medRxiv : the preprint server for health sciences · 2026Article
- Efficacy of tenoxicam for postoperative dental pain: a systematic review of randomized controlled trials.Journal of dental anesthesia and pain medicine · 2026Review
- Pharmacologic Management of Non-Traumatic Dental Conditions in US Emergency Departments, 2018-2022.Journal of public health dentistry · 2025Article
- Predictors of Supplemental Opioid Use After Third Molar Extraction.medRxiv : the preprint server for health sciences · 2025Article
- Role of Pharmacology in Dentistry: A Review of Analgesics, Antibiotics, and Local Anesthetics.Cureus · 2025Review
- Review
- Acute Pain Management Following Mandibular Third Molar Exodontia: A Bibliometric Analysis of Randomized Controlled Trials.International dental journal · 2025Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
Postsurgical dental pain is mainly driven by inflammation, particularly through the generation of prostaglandins via the cyclooxygenase system. Thus, it is no surprise that numerous randomized placebo-controlled trials studying acute pain following the surgical extraction of impacted third molars have demonstrated the remarkable efficacy of nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, naproxen sodium, etodolac, diclofenac, and ketorolac in this prototypic condition of acute inflammatory pain. Combining an optimal dose of an NSAID with an appropriate dose of acetaminophen appears to further enhance analgesic efficacy and potentially reduce the need for opioids. In addition to being on average inferior to NSAIDs as analgesics in postsurgical dental pain, opioids produce a higher incidence of side effects in dental outpatients, including dizziness, drowsiness, psychomotor impairment, nausea/vomiting, and constipation. Unused opioids are also subject to misuse and diversion, and they may cause addiction. Despite these risks, some dental surgical outpatients may benefit from a 1- or 2-d course of opioids added to their NSAID regimen. NSAID use may carry significant risks in certain patient populations, in which a short course of an acetaminophen/opioid combination may provide a more favorable benefit versus risk ratio than an NSAID regimen.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.