Evidence map›Paper›PMID 32286041›Full record

ArticleACS infectious diseases2020

Target-Based Design of Promysalin Analogues Identifies a New Putative Binding Cleft in Succinate Dehydrogenase.

Savannah J Post, Colleen E Keohane, Lauren M Rossiter, Anna R Kaplan, Jittasak Khowsathit, Katie Matuska, John Karanicolas, William M Wuest

Erratum issuedOpen access · greenAbstract read
In one paragraph

Article in ACS infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Target-Guided Design and Synthesis of Aryl-Functionalized Promysalin Analogs.Chembiochem : a European journal of chemical biology · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Savannah J PostDepartment of Chemistry, Emory University, Atlanta, Georgia 30322, United States.
Colleen E KeohaneDepartment of Chemistry, Emory University, Atlanta, Georgia 30322, United States.
Lauren M RossiterDepartment of Chemistry, Temple University, Philadelphia, Pennsylvania 19122, United States.
Anna R KaplanDepartment of Chemistry, Emory University, Atlanta, Georgia 30322, United States.
Jittasak KhowsathitMolecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, United States.
Katie MatuskaDepartment of Chemistry, Emory University, Atlanta, Georgia 30322, United States.
John KaranicolasMolecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, United States.ORCID 0000-0003-0300-726X
William M WuestDepartment of Chemistry, Emory University, Atlanta, Georgia 30322, United States.ORCID 0000-0002-5198-7744
Emory University · USFox Chase Cancer Center · USTemple University · US

Funding

WORD PROCESSING CENTER--COREP30CA006927 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI Margaret von Mehren · 1985 to 2026
$138.8M
Natural Product-Inspired Approaches Toward The Development Of Antivirulence And Species-Specific InhibitorsR35GM119426 · NIGMS · TEMPLE UNIV OF THE COMMONWEALTH · PI William M Wuest · 2016 to 2026
$4.8M
Robust Rational Design of Chemical Tools to Inhibit RNA-binding ProteinsR01GM123336 · NIGMS · RESEARCH INST OF FOX CHASE CAN CTR · PI KARANICOLAS, JOHN · 2017 to 2020
$1.5M
NCI NIH HHS P30 CA006927NIGMS NIH HHS R01 GM123336NIGMS NIH HHS R35 GM119426
6 · The paper itself

Abstract

Promysalin is a small-molecule natural product that specifically inhibits growth of the Gram-negative pathogen

Indexed as

SalicylamidesSuccinate DehydrogenaseHumansPyrrolidinespromysalinPyrrolidinesSalicylamidesSuccinate Dehydrogenaseantibioticsdiverted total synthesismolecular modelingPseudomonas aeruginosasuccinate dehydrogenase

Identifiers

PMID32286041
PMCPMC7293565
OpenAlexW3015487178

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.