ArticleESC heart failure2020
Hypochloraemia and 30 day readmission rate in patients with acute decompensated heart failure.
Article in ESC heart failure, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Prevalence of Hypochloremia in Patients With Heart Failure: A Systematic Review and Meta-Analysis.Nursing open · 2025Pooled it
- Hypochloraemia independently associates with short-term mortality in patients with acute heart failure: a study from Vietnam.Open heart · 2026Article
- Factors Predicting Diuretic Resistance in Patients With Acute Decompensated Heart Failure.Journal of clinical medicine research · 2026Article
- Do gender differences matter in Acute Heart Failure? Insights from Indian College of Cardiology - National Heart Failure Registry, India.International journal of cardiology. Cardiovascular risk and prevention · 2025Article
- Prognostic Markers of Adverse Outcomes in Acute Heart Failure: Use of Machine Learning and Network Analysis with Real Clinical Data.Journal of clinical medicine · 2025Article
- Persistent Hypochloremia Is Associated with Adverse Prognosis in Patients Repeatedly Hospitalized for Heart Failure.Journal of clinical medicine · 2023Article
- Serum Chloride Is Inversely Associated With 3 Months Outcomes in Chinese Patients With Heart Failure, a Retrospective Cohort Study.Frontiers in cardiovascular medicine · 2022Article
- Clinical physiology aspects of chloremia in fluid therapy: a systematic review.Perioperative medicine (London, England) · 2020Review
- Hypochloraemia in Patients with Heart Failure: Causes and Consequences.Cardiology and therapy · 2020Review
- Hypochloraemia and 30 day readmission rate in patients with acute decompensated heart failure.ESC heart failure · 2020Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsDespite recent advances in guideline-directed therapy, rehospitalization rates for acute decompensated heart failure (ADHF) remain high. Recently published studies demonstrated the emerging role of hypochloraemia as a predictor of poor outcomes in patients with ADHF. This study sought to determine the correlation between low serum chloride and 30 day hospital readmission in patients with ADHF. METHODS AND
resultsWe retrospectively reviewed electronic medical records of 1504 patients who were admitted to one 700 bed US tertiary care centre with the diagnosis of ADHF between June 2013 and December 2014. Of the 1504 reviewed records, 1241 were selected for further analysis. Hypochloraemia (either on admission or at discharge) was identified in 289 patients (23.3%) and was associated with significantly higher 30 day hospital readmission rate or death (42.2% vs. 33.7%, P = 0.008). This association persisted in multivariate analysis when controlling for serum sodium, weight loss, diuretic dose, adjunct thiazide use, serum blood urea nitrogen, and BNP levels (OR: 1.35, 95% CI: 1.02-1.77, P = 0.033); however, the predictive value of the overall model was low (Naglkerke R
conclusionsLow serum chloride measured in patients admitted for ADHF is independently but weakly associated with increased 30 day readmission rate and demonstrated low predictive value as a potential biomarker in this cohort.
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