ArticleInternational wound journal2020
Autologous platelet-rich plasma injection enhances healing of chronic venous leg ulcer: A prospective randomised study.
Article in International wound journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 4 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- The Effectiveness, Safety and Cost-Effectiveness of Platelet-Rich Plasma and Platelet-Rich Fibrin in the Treatment of Venous Leg Ulcers: A Systematic Review and Meta-Analysis.International wound journal · 2026Pooled it
- Clinical efficacy of blood derivatives on wound healing: A systematic review and network meta-analysis.International wound journal · 2024Pooled it
- Current art of combination therapy with autologous platelet-rich plasma for stable vitiligo: A meta-analysis.International wound journal · 2021Pooled it
- The application of platelet-rich plasma for skin graft enrichment: A meta-analysis.International wound journal · 2020Pooled it
- Platelet-Rich Plasma in a Refractory Venous Leg Ulcer Following Multiple Failed Skin Grafts.International wound journal · 2026Article
- Efficacy of mesenchymal stem cells and platelet-rich plasma therapies on wound healing: A Systematic Review and meta-analysis.Regenerative therapy · 2025Review
- [Clinical expert consensus on application of topical growth factors in chronic wounds (2025 edition)].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2025Article
- The Effect of Platelet Rich Plasma on Wound Healing in Pressure Ulcer Patient Grade III and IV.International wound journal · 2025Article
- Platelet-rich plasma and plasma rich in growth factors in extra-oral wound care.Periodontology 2000 · 2025Review
- Applications of blood plasma derivatives for cutaneous wound healing: A mini-review of clinical studies.Regenerative therapy · 2024Review
- Treatment with Umbilical Cord Blood Platelet Lysate Gel Improves Healing of Diabetic Foot Ulcer.Journal of clinical medicine · 2024Article
- Platelet-Rich Plasma in Chronic Wound Management: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.Journal of clinical medicine · 2022Review
- A case series of platelet rich plasma in chronic venous ulcers.Regenerative therapy · 2021Article
- [Research advances on the application of platelet concentrate products in wound repair].Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns · 2021Article
- Strategies and challenges in the treatment of chronic venous leg ulcers.World journal of clinical cases · 2020Review
- Autologous platelet-rich plasma injection enhances healing of chronic venous leg ulcer: A prospective randomised study.International wound journal · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Our aim was to compare the efficacy and safety of platelet-rich plasma (PRP) application versus PRP injection for chronic venous leg ulcer (VLU) healing compared with compression therapy as a control. From July 2018 to December 2019, 90 chronic VLU patients were randomly assigned to PRP dressings (n = 30), local PRP injections (n = 30), and compression therapy alone (n = 30). Standard compression accompanied both PRP groups. The main endpoints were ulcer healing and area reduction within 3, 6, and 12 months. Complications and ulcer recurrence were also recorded. The study included 72 (80.0%) males and 18 (20.0%) females aged 22 to 66 years, having VLUs for 1 to 11 years. PRP injection promoted healing (24/30, 80%) more than PRP application (20/30, 66.7%) and compression (14/30, 46.7%), P = .007. Healing time was significantly shorter after PRP injection compared with the other two groups. A greater area reduction was observed after PRP injection compared with compression at all follow-up visits, P = .013, .002, and < .001, and compared with PRP application only at 3 months post-treatment, P = .016. Recurrence and complications were comparable among the groups. PRP injection enhances the healing of chronic venous ulcers more than each of PRP application and compression therapy. All had comparable recurrence and safety.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.