ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2020
Adherence to a Mediterranean diet and cognitive function in the Age-Related Eye Disease Studies 1 & 2.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Anti-inflammatory dietary patterns and cognitive aging in older adults: a scoping review of mechanistic, clinical, and nursing implications.Frontiers in nutrition · 2026Pooled it
- Fish consumption, cognitive impairment and dementia: an updated dose-response meta-analysis of observational studies.Aging clinical and experimental research · 2024Pooled it
- Whole Dietary Patterns, Cognitive Decline and Cognitive Disorders: A Systematic Review of Prospective and Intervention Studies.Nutrients · 2023Pooled it
- Editorial: Nutrition in neurodegeneration: bridging diet, brain, and eye health.Frontiers in nutrition · 2026Article
- Impact of Diverse Dietary Patterns on Cognitive Health: Cumulative Evidence from Prospective Cohort Studies.Nutrients · 2025Review
- Management and Prevention of Neurodegenerative Disorders: Can Antioxidant-Rich Dietary Interventions Help?Antioxidants (Basel, Switzerland) · 2025Review
- Review of Supplements That Patients Commonly Report Using for Dementia.Journal of clinical medicine · 2024Review
- New Insights into the Relationship between Nutrition and Neuroinflammation in Alzheimer's Disease: Preventive and Therapeutic Perspectives.CNS & neurological disorders drug targets · 2024Review
- Gut Microbiome in Alzheimer's Disease: from Mice to Humans.Current neuropharmacology · 2024Review
- Geographic Atrophy in Age-Related Macular Degeneration: A Tale of Two Stages.Ophthalmology science · 2023Article
- Interaction between genetics and the adherence to the Mediterranean diet: the risk for age-related macular degeneration. Coimbra Eye Study Report 8.Eye and vision (London, England) · 2023Article
- Stroke-Prone SHR as Experimental Models for Cardiovascular Disease Risk Reduction in Humans.Biomedicines · 2022Article
- Gene-environment interactions in Alzheimer disease: the emerging role of epigenetics.Nature reviews. Neurology · 2022Review
- Assessing bidirectional associations between cognitive impairment and late age-related macular degeneration in the Age-Related Eye Disease Study 2.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022Article
- The combined effect of physical activity and fruit and vegetable intake on decreasing cognitive decline in older Taiwanese adults.Scientific reports · 2022Article
- Association between Dietary Diversity Changes and Cognitive Impairment among Older People: Findings from a Nationwide Cohort Study.Nutrients · 2022Article
- Maternal diet quality during pregnancy and child cognition and behavior in a US cohort.The American journal of clinical nutrition · 2022Article
- Regulation of blood-brain barrier integrity by microbiome-associated methylamines and cognition by trimethylamine N-oxide.Microbiome · 2021Article
- Age-Related Cognitive Decline May Be Moderated by Frequency of Specific Food Products Consumption.Nutrients · 2021Article
- Associations of Metabolic Genes (International journal of environmental research and public health · 2021Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
introductionThe objective was to determine whether closer adherence to the alternative Mediterranean Diet (aMED) was associated with altered cognitive function.
methodsObservational analyses of participants (n = 7,756) enrolled in two randomized trials of nutritional supplements for age-related macular degeneration: Age-Related Eye Disease Study (AREDS) and AREDS2.
resultsOdds ratios for cognitive impairment, in aMED tertile 3 (vs 1), were 0.36 (P = .0001) for Modified Mini-Mental State (<80) and 0.56 (P = .001) for composite score in AREDS, and 0.56 for Telephone Interview Cognitive Status-Modified (<30) and 0.48 for composite score (each P < .0001) in AREDS2. Fish intake was associated with higher cognitive function. In AREDS2, rate of cognitive decline over 5 to 10 years was not significantly different by aMED but was significantly slower (P = .019) with higher fish intake. DISCUSSION: Closer Mediterranean diet adherence was associated with lower risk of cognitive impairment but not slower decline in cognitive function. Apolipoprotein E (APOE) haplotype did not influence these relationships.
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