Evidence map›Paper›PMID 32285422›Full record

ReviewAdvances in experimental medicine and biology2020

Y RNAs: Biogenesis, Function and Implications for the Cardiovascular System.

Nedyalka Valkov, Saumya Das

Abstract readReview
In one paragraph

Review in Advances in experimental medicine and biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. The dark genome in cardiovascular medicine.European heart journal · 2026
    Review
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  4. Sialylation in the nervous system: Functions and mechanisms.The Journal of biological chemistry · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Nedyalka ValkovCardiovascular Research Center of Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Saumya DasCardiovascular Research Center of Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. sdas@mgh.harvard.edu.

Funding

MULTIDISCIPLINARY RESEARCH TRAINING IN CARDIOLOGYT32HL007208 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Patrick Thomas Ellinor, David E Sosnovik · 1985 to 2026
$16.1M
Novel Role for Circulating extracellular RNAs in Human Heart FailureR01HL122547 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI DAS, SAUMYA · 2015 to 2019
$2.1M
NHLBI NIH HHS R01 HL122547NHLBI NIH HHS T32 HL007208
6 · The paper itself

Abstract

In recent years, progress in the field of high-throughput sequencing technology and its application to a wide variety of biological specimens has greatly advanced the discovery and cataloging of a diverse set of non-coding RNAs (ncRNAs) that have been found to have unexpected biological functions. Y RNAs are an emerging class of highly conserved, small ncRNAs. There is a growing number of reports in the literature demonstrating that Y RNAs and their fragments are not just random degradation products but are themselves bioactive molecules. This review will outline what is currently known about Y RNA including biogenesis, structure and functional roles. In addition, we will provide an overview of studies reporting the presence and functions attributed to Y RNAs in the cardiovascular system.

Indexed as

Cardiovascular SystemRNA, Small UntranslatedHumansRNA, Small UntranslatedCardiovascular diseasesNon-coding RNAY RNA

Identifiers

PMID32285422
PMCPMC7363058

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.