Evidence map›Paper›PMID 32285344›Full record

ArticleAnnals of biomedical engineering2020

Dynamic Modulation of Device-Arterial Coupling to Determine Cardiac Output and Vascular Resistance.

Steven P Keller, Brian Y Chang, Qing Tan, Zhengyang Zhang, Ahmad El Katerji, Elazer R Edelman

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of biomedical engineering, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Steven P KellerInstitute for Medical Engineering and Science, Massachusetts Institutes of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA. spkeller@mit.edu.ORCID http://orcid.org/0000-0002-3870-9811
Brian Y ChangInstitute for Medical Engineering and Science, Massachusetts Institutes of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA.
Qing TanAbiomed Inc., Danvers, MA, 01923, USA.
Zhengyang ZhangInstitute for Medical Engineering and Science, Massachusetts Institutes of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA.
Ahmad El KaterjiAbiomed Inc., Danvers, MA, 01923, USA.
Elazer R EdelmanInstitute for Medical Engineering and Science, Massachusetts Institutes of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA.
Abiomed (United States) · USBrigham and Women's Hospital · USMassachusetts Institute of Technology · US

Funding

Vascular Drug Delivery - Supplement for EquipmentR01GM049039 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI EDELMAN, ELAZER R · 1994 to 2019
$8.9M
Functional restoration of ventriculo-arterial coupling in cardiogenic shock via dual mechanical supportK08HL143342 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI KELLER, STEVEN PAUL · 2018 to 2023
$853k
NHLBI NIH HHS K08 HL143342NHLBI NIH HHS K08HL14334202NIGMS NIH HHS R01 GM049039NIGMS NIH HHS R01GM04903924
6 · The paper itself

Abstract

Clinical adoption of mechanical circulatory support for shock is rapidly expanding. Achieving optimal therapeutic benefit requires metrics of state to guide titration and weaning of support. Using the transvalvular positioning of a percutaneous ventricular assist device (pVAD), device:heart interactions are leveraged to determine cardiac output (CO) and systemic vascular resistance (SVR) near-continuously without disrupting therapeutic function. An automated algorithm rapidly alternates between device support levels to dynamically modulate physiological response. Employing a two-element lumped parameter model of the vasculature, SVR and CO are quantified directly from measurements obtained by the pVAD without external calibration or invasive catheters. The approach was validated in an acute porcine model across a range of cardiac (CO = 3-10.6 L/min) and vascular (SVR = 501-1897 dyn s/cm

Indexed as

Cardiac OutputCathetersHeart-Assist DevicesModels, CardiovascularVascular ResistanceAnimalsArteriesHumansShock, CardiogenicSwineCardiogenic shockMechanical circulatory supportVentricular assist device

Identifiers

PMID32285344
PMCPMC7483564
OpenAlexW3016002336

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.