Observational studyJournal of pharmacokinetics and pharmacodynamics2020
A longitudinal item response model for Aberrant Behavior Checklist (ABC) data from children with autism.
Observational study in Journal of pharmacokinetics and pharmacodynamics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- rTMS Modulates Static and Dynamic Brain Functional Networks in Children with Autism Spectrum Disorder: An EEG Microstate Study.Brain topography · 2026Trial
- [A prospective randomized controlled study of neurofeedback combined with learning style profile intervention training in children with high-functioning autism].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2024Trial
- Drug Repurposing for Treating NCOR-Related Intellectual Disability.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- The effect of fully immersive virtual reality technology combined with psychological and behavioral intervention on autism spectrum disorder.BMC psychology · 2025Article
- Predicting the diagnostic efficacy of trio-based whole exome sequencing in children with low-function autism spectrum disorders: a multicenter study.Frontiers in neurology · 2025Article
- Comparison of the power and type 1 error of total score models for drug effect detection in clinical trials.Journal of pharmacokinetics and pharmacodynamics · 2024Article
- Item performance of the scale for the assessment and rating of ataxia in rare and ultra-rare genetic ataxias.CPT: pharmacometrics & systems pharmacology · 2024Article
- Phenotypic and genetic analysis of children with unexplained neurodevelopmental delay and neurodevelopmental comorbidities in a Chinese cohort using trio-based whole-exome sequencing.Orphanet journal of rare diseases · 2024Article
- Development and Psychometric Evaluation of the Open-Source Challenging Behavior Scale (OS-CBS).Journal of autism and developmental disorders · 2023Article
- Non-invasive brain stimulation for patient with autism: a systematic review and meta-analysis.Frontiers in psychiatry · 2023Review
- Assessing the effect of child's gender on their father-mother perception of the PedsQL™ 4.0 questionnaire: an iterative hybrid ordinal logistic regression/item response theory approach with Monte Carlo simulation.Health and quality of life outcomes · 2020Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
This manuscript aims to present the first item response theory (IRT) model within a pharmacometric framework to characterize the longitudinal changes of Aberrant Behavior Checklist (ABC) data in children with autism. Data were obtained from 120 patients, which included 20,880 observations of the 58 items for up to three months. Observed scores for each ABC item were modeled as a function of the subject's disability. Longitudinal IRT models with five latent disability variables based on ABC subscales were used to describe the irritability, lethargy, stereotypic behavior, hyperactivity, and inappropriate speech over time. The IRT pharmacometric models could accurately describe the longitudinal changes of the patient's disability while estimating different time-course of disability for the subscales. For all subscales, model-estimated disability was reduced following initiation of therapy, most markedly for hyperactivity. The developed framework provides a description of ABC longitudinal data that can be a suitable alternative to traditional ABC data collected in autism clinical trials. IRT is a powerful tool with the ability to capture the heterogeneous nature of ABC, which results in more accurate analysis in comparison to traditional approaches.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.