Evidence map›Paper›PMID 32285251›Full record

Trial reportSleep & breathing = Schlaf & Atmung2021

Impact of concomitant obstructive sleep apnea on pulmonary involvement and main pulmonary artery diameter in adults with scleroderma.

Tugce Yakut, Baran Balcan, Sait Karakurt, Haner Direskeneli, Yasemin Yalcinkaya, Yüksel Peker

Registry-linked trialOpen access · hybridAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Sleep & breathing = Schlaf & Atmung, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02740569 (Obstructive Sleep Apnea in Scleroderma and Pulmonary Involvement), which is not on this map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02740569 completednot on this map

Obstructive Sleep Apnea in Scleroderma and Pulmonary Involvement

TypeobservationalSponsorMarmara UniversityRan2016 to 2016Enrolled62ConditionsScleroderma, Systemic, Sleep Apnea, Obstructive, Pulmonary DiseaseArmsNo intervention
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Pulmonary artery dilatation and obstructive sleep apnea.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Tugce YakutDepartment of Allergology and Immunology, Süreyyapasa Chest Diseases and Chest Surgery Training & Research Hospital, Istanbul, Turkey.
Baran BalcanDepartment of Pulmonary Medicine, Marmara University, School Medicine, Istanbul, Turkey.
Sait KarakurtDepartment of Pulmonary Medicine, Marmara University, School Medicine, Istanbul, Turkey.
Haner DireskeneliDepartment of Rheumatology, School of Medicine, Marmara University, Istanbul, Turkey.
Yasemin YalcinkayaDepartment of Rheumatology, School of Medicine, Marmara University, Istanbul, Turkey.
Yüksel PekerDepartment of Pulmonary Medicine, School of Medicine, Koc University, Koc University Hospital, Davutpasa cad, No. 4, Zeytinburnu, TR-34010, Istanbul, Turkey. yuksel.peker@lungall.gu.se.
Marmara University · TRKoç University · TRYedikule Teaching Hospital · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePulmonary involvement is common in adults with scleroderma. The effect of concomitant obstructive sleep apnea (OSA) on risk for pulmonary hypertension in scleroderma is unknown. An enlarged main pulmonary artery diameter (mPAD) derived from chest computer tomography (CT) is a useful predictor of pulmonary hypertension. We addressed the effect of OSA on pulmonary involvement and enlarged mPAD in adults with scleroderma.

methodsAll participants underwent pulmonary function testing, carbon monoxide diffusion capacity, chest CT, and overnight sleep recording with home sleep apnea testing. OSA diagnosis was based on an apnea-hypopnea index (AHI) ≥ 15/h. Oxygen desaturation index (ODI) was also recorded. Scleroderma involvement of the lungs was defined as the Warrick score ≥ 7 based on the CT findings. Enlarged mPAD was defined as an mPAD ≥ 29 mm in men and ≥ 27 mm in women.

resultsAfter exclusions, 62 patients (58 women) were included. OSA was found among 20 (32%), 17/42 (38%) in the limited cutaneous type, and 3/20 (15%) in the diffuse cutaneous type (p = 0.08). Scleroderma involvement of the lungs was observed in 40 participants (65% in OSA vs 64% in no-OSA; n.s.). Enlarged mPAD was measured in 16 participants, 10 of 20 (50%) in the OSA group and 6 of 17 (14%) in the no-OSA group (p = 0.003). OSA was associated with enlarged mPAD (odds ratio 4.7, 95% confidence interval 1.1-20.9; p = 0.042) independent of age, body mass index, and pulmonary involvement. There was a linear relationship between mPAD and AHI (r = 0.37; p = 0.003) as well as ODI (r = 0.41; p < 0.001).

conclusionsIn this cohort, OSA was associated with risk for pulmonary hypertension independent of pulmonary involvement. These findings suggest that assessing the effect of therapy for concomitant OSA in patients with scleroderma is warranted.

trial registrationNCT02740569.

Indexed as

AdultAgedCross-Sectional StudiesFemaleHumansHypertension, PulmonaryMaleMiddle AgedPulmonary ArteryPulmonary FibrosisRespiratory Function TestsScleroderma, DiffuseScleroderma, LimitedSkin DiseasesSleep Apnea, ObstructiveTomography, X-Ray ComputedObstructive sleep apneaPulmonary hypertensionPulmonary involvementScleroderma

Identifiers

PMID32285251
PMCPMC7987605
OpenAlexW3015365565

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.