ArticleOdontology2021
Alteration of cytokines in saliva of children with caries and obesity.
Article in Odontology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Activity and levels of TNF-α, IL-6 and IL-8 in saliva of children and young adults with dental caries: a systematic review and meta-analysis.BMC oral health · 2024Pooled it
- [Reported prevalence of dental caries in Mexican children and teenagers].Revista medica del Instituto Mexicano del Seguro Social · 2023Pooled it
- Obesity and oral health in Mexican children and adolescents: systematic review and meta-analysis.Nutrition reviews · 2022Pooled it
- Genetic evidence for causal link between systemic inflammation and dental caries risk: A bidirectional Mendelian randomization study.Medicine · 2026Article
- Obesity and Dental Caries: A State-of-the-Art Review of Shared Risk Factors, Biological Mechanisms and Current Evidence.Medical sciences (Basel, Switzerland) · 2026Review
- In Silico Identification of Dual-Action Compounds Targeting TLR2 andDentistry journal · 2026Article
- Systemic Inflammatory and Hematologic Biomarkers in Pediatric Dental Caries: Clear Group Differences with Limited Independent Association with DMFT.Journal of clinical medicine · 2026Article
- Influence of Behavioral and Sociodemographic Factors on Dental Caries in Mexican Children.Pediatric reports · 2025Article
- Association between overweight/obesity and dental outcomes in early childhood: Findings from an Australian cohort study.Community dentistry and oral epidemiology · 2025Article
- Is there an association between salivary immune and microbial profile with dental health in systematically healthy children?Clinical oral investigations · 2024Article
- Pomegranate Extract Potentiates the Anti-Demineralizing, Anti-Biofilm, and Anti-Inflammatory Actions of Non-Alcoholic Mouthwash When Associated with Sodium-Fluoride Trimetaphosphate.Antibiotics (Basel, Switzerland) · 2022Article
- Development and validation of an LC-MS/MS method for determination of 8-iso-prostaglandin f2 Alpha in human saliva.Journal of medical biochemistry · 2022Article
- Sinapic acid restores blood parameters, serum antioxidants, and liver and kidney functions in obesity.Journal of diabetes and metabolic disorders · 2022Article
- Analysis of ghrelin, leptin, and interleukin-6 salivary concentration among children aged 7-10 years and its relationship with nutritional status and some anthropometric data.Pediatric endocrinology, diabetes, and metabolism · 2022Article
- Exercise Outcomes in Childhood Obesity-Related Inflammation and Oxidative Status.Frontiers in nutrition · 2022Review
- Leukocytes and Neutrophil-Lymphocyte Ratio as Indicators of Insulin Resistance in Overweight/Obese School-Children.Frontiers in nutrition · 2021Article
- Impact of COVID-19 on Children and Young Adults With Type 2 Diabetes: A Narrative Review With Emphasis on the Potential of Intermittent Fasting as a Preventive Strategy.Frontiers in nutrition · 2021Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Caries and obesity are multifactorial diseases with inflammatory components, whose processes involve cells and molecules, such as cytokines. Therefore, the objective of this work was to compare the concentrations of IL-6, IL-8, IL-15, and IL-18 in the salivary samples of children with caries and obesity. The study was carried out with 80 children: 43 with a normal weight and 37 with obesity. The diagnosis of caries was carried out using the ICDAS system. Salivary samples were used to measure the cytokine levels via the ELISA technique. Our results show that children with obesity and dental cavities have high levels of IL-6 and IL-15. Similarly, obese children have elevated levels of these two cytokines, while children with cavitated carious lesions presented alterations in their concentrations of IL-6 and IL-8. In conclusion, our data suggest that IL-6 has a significant effect on both obesity and caries, although IL-8 is more related to caries, and IL-15 is more related to obesity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.