Evidence map›Paper›PMID 32285180›Full record

ArticleAbdominal radiology (New York)2020

Inter-observer variability of radiologists for Cambridge classification of chronic pancreatitis using CT and MRCP: results from a large multi-center study.

Temel Tirkes, Zarine K Shah, Naoki Takahashi, Joseph R Grajo, Stephanie T Chang, Ashley M Wachsman, Kareem Mawad, Carlos A Farinas, Liang Li, Savitri N Appana and 4 more

Open access · greenAbstract readMulticenter Study
In one paragraph

Article in Abdominal radiology (New York), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 21 citations in OpenAlex.

  1. Advances in MRI of Chronic Pancreatitis.Advances in clinical radiology · 2024
    Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. High Prevalence of Osteopathy in Chronic Pancreatitis: A Cross-sectional Analysis From the PROCEED Study.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2022
    Observational
  7. Article
  8. Article
  9. Secretin-Enhanced MRCP: How and Why-AJR. American journal of roentgenology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 11 institutions in 1 country.

Temel TirkesDepartment of Radiology and Imaging Sciences, Indiana University School of Medicine, 550 N. University Blvd. Suite 0663, Indianapolis, IN, 46202, USA. atirkes@iu.edu.ORCID 0000-0002-0185-8741
Zarine K ShahDepartment of Radiology, Ohio State University Wexner Medical Center, Columbus, OH, USA.
Naoki TakahashiDepartment of Radiology, Mayo Clinic, Rochester, MN, USA.
Joseph R GrajoUniversity of Florida College of Medicine, Gainesville, FL, USA.
Stephanie T ChangDepartment of Radiology and Division of Body MRI, Stanford University School of Medicine, Stanford, CA, USA.
Ashley M WachsmanDepartment of Radiology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Kareem MawadDepartment of Radiology, South San Francisco Medical Center, The Permanente Medical Group, South San Francisco, CA, USA.
Carlos A FarinasDepartment of Radiology, Baylor College of Medicine, Houston, TX, USA.
Liang LiDepartment of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Savitri N AppanaDepartment of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Darwin L ConwellDivision of Gastroenterology, Department of Medicine, Ohio State University Wexner Medical Center, Hepatology & Nutrition, Columbus, OH, USA.
Dhiraj YadavDivision of Gastroenterology, Hepatology & Nutrition, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Anil K DasyamDepartment of Radiology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Consortium for the Study of Chronic Pancreatitis, Diabetes, Pancreatic Cancer
The Ohio State University Wexner Medical Center · USThe University of Texas MD Anderson Cancer Center · USBaylor College of Medicine · USCedars-Sinai Medical Center · USIndiana University School of MedicineKaiser Permanente South San Francisco Medical Center · USMayo Clinic in Arizona · USStanford University · USUniversity of Florida · USUniversity of Pittsburgh · USUniversity of Pittsburgh Medical Center · US

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Fabien Delerue · 1985 to 2026
$290.8M
Indiana University (IU) Clinical Center for Chronic Pancreatitis Clinical Research NetworkU01DK108323 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI Jeffrey James Easler, Evan L Fogel · 2015 to 2026
$6.5M
UPMC Clinical Center for the Study of Chronic Pancreatitis and DiabetesU01DK108306 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Frederico G. S. Toledo, Dhiraj Yadav · 2015 to 2026
$6.4M
The Stanford Clinical Center for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic CancerU01DK108300 · NIDDK · STANFORD UNIVERSITY · PI Sohail Z Husain, Walter Gwang-Up Park · 2015 to 2026
$6.3M
Pathophysiology, Epidemiology, and Prevention of Pancreatogenic Diabetes - Administrative SupplementU01DK108314 · NIDDK · CEDARS-SINAI MEDICAL CENTER · PI Mark Goodarzi, Stephen J. Pandol · 2015 to 2026
$6.1M
The Exocrine and Endocrine Pancreas in Type 2 Diabetes, Pancreatitis and Cancer (Admin Supplement)U01DK108288 · NIDDK · MAYO CLINIC ROCHESTER · PI Santhi Swaroop Vege · 2015 to 2026
$5.9M
The Ohio State University Pancreatic Disorders Network (OSU-PDN)U01DK108327 · NIDDK · OHIO STATE UNIVERSITY · PI CONWELL, DARWIN LEWIS, HART, PHILIP A. · 2015 to 2024
$5.5M
Magnetic resonance Imaging as a Non-Invasive Method for Assessment of Pancreatic fibrosis (MINIMAP): a pilot studyR01DK116963 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI FOGEL, EVAN L, TIRKES, TEMEL · 2018 to 2020
$2.0M
NCI NIH HHS P30 CA016672NIDDK NIH HHS R01 DK116963NIDDK NIH HHS U01 DK108288NIDDK NIH HHS U01 DK108300NIDDK NIH HHS U01 DK108306NIDDK NIH HHS U01 DK108314NIDDK NIH HHS U01 DK108323NIDDK NIH HHS U01 DK108327
6 · The paper itself

Abstract

purposeDetermine inter-observer variability among radiologists in assigning Cambridge Classification (CC) of chronic pancreatitis (CP) based on magnetic resonance imaging (MRI)/magnetic resonance cholangiopancreatography (MRCP) and contrast-enhanced CT (CECT).

methodsAmong 422 eligible subjects enrolled into the PROCEED study between 6/2017 and 8/2018, 39 were selected randomly for this study (chronic abdominal pain (n = 8; CC of 0), suspected CP (n = 22; CC of 0, 1 or 2) or definite CP (n = 9; CC of 3 or 4). Each imaging was scored by the local radiologist (LRs) and three of five central radiologists (CRs) at other consortium sites. The CRs were blinded to clinical data and site information of the participants. We compared the CC score assigned by the LR with the consensus CC score assigned by the CRs. The weighted kappa statistic (K) was used to estimate the inter-observer agreement.

resultsFor the majority of subjects (34/39), the group assignment by LR agreed with the consensus composite CT/MRCP score by the CRs (concordance ranging from 75 to 89% depending on cohort group). There was moderate agreement (63% and 67% agreed, respectively) between CRs and LRs in both the CT score (weighted Kappa [95% CI] = 0.56 [0.34, 0.78]; p-value = 0.57) and the MR score (weighted Kappa [95% CI] = 0.68 [0.49, 0.86]; p-value = 0.72). The composite CT/MR score showed moderate agreement (weighted Kappa [95% CI] = 0.62 [0.43, 0.81]; p-value = 0.80).

conclusionThere is a high degree of concordance among radiologists for assignment of CC using MRI and CT.

Indexed as

Cholangiopancreatography, Magnetic ResonanceTomography, X-Ray ComputedAdultAgedContrast MediaFemaleHumansMaleMiddle AgedObserver VariationPancreatitis, ChronicRadiologistsSeverity of Illness IndexContrast MediaChronic pancreatitisComputerized tomographyInter-observer variabilityMagnetic resonance cholangiopancreatography

Identifiers

PMID32285180
PMCPMC7233445
OpenAlexW3016009925

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.