ReviewApplied microbiology and biotechnology2020
Microbial acetylcholinesterase inhibitors for Alzheimer's therapy: recent trends on extraction, detection, irradiation-assisted production improvement and nano-structured drug delivery.
Review in Applied microbiology and biotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Evaluation of the antibacterial and antibiofilm effect of mycosynthesized silver and selenium nanoparticles and their synergistic effect with antibiotics on nosocomial bacteria.Microbial cell factories · 2025Article
- Exploring New Structures of Kinase Inhibitors and Multitarget Strategies in Alzheimer's Disease Treatment.Protein and peptide letters · 2025Review
- Novel Emerging Targets Identification in Reducing Risk of Alzheimer's Disease.Central nervous system agents in medicinal chemistry · 2025Review
- Multifaceted bioactivity of marine fungal derived secondary metabolite, xyloketal B -a review.Toxicology research · 2024Review
- Article
- Microorganism-Derived Molecules as Enzyme Inhibitors to Target Alzheimer's Diseases Pathways.Pharmaceuticals (Basel, Switzerland) · 2023Review
- Potential Anti-Cholinesterase Activity of Bioactive Compounds Extracted fromPlants (Basel, Switzerland) · 2023Article
- Bioprospecting endophytic fungi for antifeedants and larvicides and their enhancement by gamma irradiation.AMB Express · 2022Article
- Assessment of Pharmacological Potential of Novel Exopolysaccharide Isolated from MarineLife (Basel, Switzerland) · 2022Article
- Two New Picoline-Derived Meroterpenoids with Anti-Acetylcholinesterase Activity from Ascidian-Derived FungusMolecules (Basel, Switzerland) · 2022Article
- A new endophyte Monascus ruber SRZ112 as an efficient production platform of natural pigments using agro-industrial wastes.Scientific reports · 2022Article
- Harnessing endophytic fungi for biosynthesis of selenium nanoparticles and exploring their bioactivities.AMB Express · 2022Article
- Bioprospecting endophytic fungi for bioactive metabolites and use of irradiation to improve their bioactivities.AMB Express · 2022Article
- Exploiting the exceptional biosynthetic potency of the endophyticSaudi journal of biological sciences · 2022Article
- Isolation and acetylcholinesterase inhibitory activity of asterric acid derivatives produced by3 Biotech · 2022Article
- New and potent production platform of the acetylcholinesterase inhibitor huperzine A by gamma-irradiated Alternaria brassicae under solid-state fermentation.Applied microbiology and biotechnology · 2021Article
- A ratiometric fluorescence strategy based on inner filter effect for CuMikrochimica acta · 2021Article
- Molecular identification and evaluation of gamma irradiation effect on modulating heavy metals tolerance in some of novel endophytic fungal strains.Archives of microbiology · 2021Article
- The Antiviral Drug Tilorone Is a Potent and Selective Inhibitor of Acetylcholinesterase.Chemical research in toxicology · 2021Article
- Novel mycosynthesis of CoApplied microbiology and biotechnology · 2021Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neurodegenerative disorders especially Alzheimer's disease (AD) are significantly threatening the public health. Acetylcholinesterase (AChE) inhibitors are compounds of great interest which can be used as effective agents for the symptomatic treatment of AD. Although plants are considered the largest source for these types of inhibitors, the microbial production of AChE inhibitors represents an efficient, easily manipulated, eco-friendly, cost-effective, and alternative approach. This review highlights the recent advances on the microbial production of AChE inhibitors and summarizes all the previously reported successful studies on isolation, screening, extraction, and detecting methodologies of AChE inhibitors from the microbial fermentation, from the earliest trials to the most promising anti-AD drug, huperzine A (HupA). In addition, improvement strategies for maximizing the industrial production of AChE inhibitors by microbes will be discussed. Finally, the promising applications of nano-material-based drug delivery systems for natural AChE inhibitor (HupA) will also be summarized. KEY POINTS: • AChE inhibitors are potential therapies for Alzheimer's disease. • Microorganisms as alternate sources for prospective production of such inhibitors. • Research advances on extraction, detection, and strategies for production improvement. • Nanotechnology-based approaches for an effective drug delivery for Alzheimer's disease.
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Registered trials
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