Evidence map›Paper›PMID 32285152›Full record

ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2020

Role of Fibronectin-1 polymorphism genes with the pathogenesis of intraventricular hemorrhage in preterm infants.

Dawid Szpecht, Salwan R Al-Saad, Lukasz M Karbowski, Katarzyna Kosik, Grażyna Kurzawińska, Marta Szymankiewicz, Krzysztof Drews, Agnieszka Seremak-Mrozikiewicz

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In one paragraph

Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Hemangioma-related gene polymorphisms in the pathogenesis of intraventricular hemorrhage in preterm infants.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Dawid SzpechtChair and Department of Neonatology, Poznan University of Medical Sciences, Poznan, Poland. dawid.szpecht@poczta.fm.
Salwan R Al-SaadPoznan University of Medical Sciences, Poznan, Poland.
Lukasz M KarbowskiPoznan University of Medical Sciences, Poznan, Poland.
Katarzyna KosikChair and Department of Neonatology, Poznan University of Medical Sciences, Poznan, Poland.
Grażyna KurzawińskaDepartment of Perinatology and Women's Diseases, Poznan University of Medical Sciences, Poznan, Poland.
Marta SzymankiewiczChair and Department of Neonatology, Poznan University of Medical Sciences, Poznan, Poland.
Krzysztof DrewsDepartment of Perinatology and Women's Diseases, Poznan University of Medical Sciences, Poznan, Poland.
Agnieszka Seremak-MrozikiewiczDepartment of Perinatology and Women's Diseases, Poznan University of Medical Sciences, Poznan, Poland.
Poznan University of Medical Sciences · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

introductionIntraventricular hemorrhage (IVH) is a dangerous complication facing a significant proportion of preterm infants. It is multifactorial in nature, and an observed fibronectin deficiency in the germinal matrix basal lamina is among the most prominent factors that influence such rupture. Better understanding of the FN1 gene polymorphisms and their role in IVH may further clarify the presence of a genetic susceptibility of certain babies to this complication. The aim of this study was to assess if 5 single nucleotide polymorphisms of the fibronectin gene may be linked to an increased incidence of IVH. MATERIAL AND

methodsThe study included 108 infants born between 24 and 32 weeks of gestation. IVH was diagnosed using cranial ultrasound performed on the 1st,3rd, and 7th day after birth and classified according to Papile et al. IVH classification. The 5 FN1 gene polymorphisms assessed in the study were the following: rs3796123; rs1968510; rs10202709; rs6725958; and rs35343655.

resultsIVH developed in 51 (47.2%) out of the 108 preterm infants. This includes, 18 (35.3%) with stage I IVH, 19 (37.3%) with stage II, 11 (21.6%) with stage III, and 3 (5.9%) with stage IV IVH. Incidence of IVH was higher in infants with lower APGAR scores, low gestational age, and low birthweight. Analysis showed that IVH stage II to IV was approximately seven times more likely to occur in infants with the genotype TT FN1 rs10202709 (OR 7237 (1046-79.59; p = 0,044)). No other significant association was found with the rest of the polymorphisms.

conclusionThe results of our study indicate a sevenfold increased genetic susceptibility to IVH in preterm infants with the TT FN1 rs10202709 gene polymorphism. The fibronectin gene polymorphism may therefore be of crucial importance as a genetic risk factor for IVH in preterm infants. Further studies are warranted.

Indexed as

Infant, PrematureInfant, Premature, DiseasesCerebral HemorrhageFibronectinsGestational AgeHumansInfantInfant, NewbornFibronectinsFibronectin-1Intraventricular hemorrhagePolymorphism genesPreterm infants

Identifiers

PMID32285152
PMCPMC7355268
OpenAlexW3015641246

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.