ArticleThe Journal of clinical endocrinology and metabolism2020
Associations Between Antihypertensive Medications and Severe Hyponatremia: A Swedish Population-Based Case-Control Study.
Article in The Journal of clinical endocrinology and metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- Thiazides and Risk of Hyponatremia by Age and Sex.JAMA network open · 2026Article
- Drug-Induced Hyponatremia Surveillance: A disproportionality analysis based on FAERs database.Pakistan journal of medical sciences · 2026Article
- Hyponatraemia After Hip and Knee Replacement: Incidence, Risk Factors, Clinical Consequences and Management in the Era of Enhanced Recovery.Clinics and practice · 2025Review
- Urine Sodium Excretion in Children with Primary Hypertension: A Single-Center Retrospective Study.Journal of clinical medicine · 2025Article
- Drug-Induced Hyponatremia: Insights into Pharmacological Mechanisms and Clinical Practice Management.Journal of clinical medicine · 2025Review
- Article
- An Instant Relationship Between Hyponatremia, Geriatric Syndromes, and Drugs in Older Adults: A Cross-Sectional Analysis from a Single Geriatric Clinic.Diagnostics (Basel, Switzerland) · 2025Article
- Impact of hypotonic hyponatremia on outcomes in patients undergoing transcatheter aortic valve replacement: a national inpatient sample.BMC cardiovascular disorders · 2025Article
- Validation of ICD-10 codes used to identify the main reason for hospitalization due to hyponatremia in Sweden.PloS one · 2025Article
- Collegiate Marching Band Artists Self-Report Previous Exercise-Associated Hyponatremia: A Cross-Sectional Study.Nutrients · 2024Article
- Effect of preparation method for radioactive iodine therapy on serum electrolytes.Japanese journal of radiology · 2023Article
- Epidemiology and predictors of hyponatremia in a contemporary cohort of patients with malignancy: a retrospective cohort study.Clinical kidney journal · 2023Article
- Prospective, multicentre study of screening, investigation and management of hyponatraemia after subarachnoid haemorrhage in the UK and Ireland.Stroke and vascular neurology · 2023Review
- Laboratory medicine in arterial hypertension.Biochemia medica · 2023Review
- Hyponatremia in patients with arterial hypertension: pathophysiology and management.Archives of medical science : AMS · 2023Article
- Syndrome of inappropriate antidiuretic hormone secretion is associated with different proton pump inhibitor use: a pharmacovigilance study.BMC nephrology · 2022Article
- Current and Future Burdens of Heat-Related Hyponatremia: A Nationwide Register-Based Study.The Journal of clinical endocrinology and metabolism · 2022Article
- Time-dependent association between selective serotonin reuptake inhibitors and hospitalization due to hyponatremia.Journal of psychopharmacology (Oxford, England) · 2021Article
- Psychotropic drug-induced hyponatremia: results from a drug surveillance program-an update.Journal of neural transmission (Vienna, Austria : 1996) · 2021Article
- Prevalence of hyponatremia among medically hospitalized patients and associated outcomes: a retrospective cohort study.Annals of Saudi medicineArticle
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCalcium channel blockers (CCBs), beta-receptor blockers (BBs), angiotensin-converting enzyme inhibitors (ACEIs), and angiotensin II receptor blockers (ARBs) have occasionally been reported to cause severe hyponatremia. The aim was to explore the association between CCBs, BBs, ACEIs, and ARBs and hospitalization due to hyponatremia.
methodsPatients hospitalized with a principal diagnosis of hyponatremia (n = 11 213) were compared with matched controls (n = 44 801). Linkage of national population-based registers was used to acquire data. Multivariable logistic regression adjusting for co-medications, diseases, previous hospitalizations, and socioeconomic factors was used to explore the association between hospitalization for severe hyponatremia and the use of different CCBs, BBs, ACEIs, and ARBs. Furthermore, newly initiated (≤90 days) and ongoing use were examined separately.
resultsAdjusted odds ratios (aORs) (95% confidence interval) for the investigated 4 drug classes ranged from 0.86 (0.81-0.92) for CCBs to 1.15 (1.07-1.23) for ARBs. For newly initiated drugs, aORs spanned from 1.64 (1.35-1.98) for CCBs to 2.24 (1.87-2.68) for ACEIs. In contrast, the corresponding associations for ongoing therapy were not elevated, ranging from 0.81 (0.75-0.86) for CCBs to 1.08 (1.00-1.16) for ARBs. In the CCBs subgroups, aOR for newly initiated vascular CCBs was 1.95 (1.62-2.34) whereas aOR for ongoing treatment was 0.82 (0.77-0.88).
conclusionsFor newly initiated CCBs, BBs, ACEIs, and ARBs, the risk of hospitalization due to hyponatremia was moderately elevated. In contrast, there was no evidence that ongoing treatment with investigated antihypertensive drugs increased the risk for hospitalization due to hyponatremia.
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