Evidence map›Paper›PMID 32284997›Full record

ArticleScience advances2020

Eradication of tumor growth by delivering novel photothermal selenium-coated tellurium nanoheterojunctions.

Shiyou Chen, Chenyang Xing, Dazhou Huang, Chuanhong Zhou, Bo Ding, Ziheng Guo, Zhengchun Peng, Dou Wang, Xi Zhu, Shuzhen Liu and 12 more

Abstract read
In one paragraph

Article in Science advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed.

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  8. Periodic Table of Immunomodulatory Elements and Derived Two-Dimensional Biomaterials.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
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  14. Multifunctional Au@AgBiSAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Shiyou ChenShenzhen Engineering Laboratory of Phosphorene and Optoelectronics, International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of Education, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, P.R. China.ORCID 0000-0002-2878-3305
Chenyang XingShenzhen Engineering Laboratory of Phosphorene and Optoelectronics, International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of Education, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, P.R. China.ORCID 0000-0002-2521-529X
Dazhou HuangShenzhen Engineering Laboratory of Phosphorene and Optoelectronics, International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of Education, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, P.R. China.
Chuanhong ZhouShenzhen Engineering Laboratory of Phosphorene and Optoelectronics, International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of Education, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, P.R. China.
Bo DingDepartment of Respiratory Disease, The Fourth Hospital of Jinan, Jinan, Shandong 250031, P.R. China.
Ziheng GuoDepartment Pancreatic Surgery, West China School of Medicine, Sichuan University, Chengdu, P.R. China.
Zhengchun PengCenter for Stretchable Electronics and Nanoscale Systems, Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, P.R. China.
Dou WangDepartment of Hepatobiliary and Pancreatic Surgery, Shenzhen People's Hospital, The First Affiliated Hospital of Southern University of Science and Technology, Shenzhen 518020, Guangdong, P.R. China.
Xi ZhuSchool of Science and Engineering, The Chinese University of Hong Kong, Shenzhen, Shenzhen 518172, P.R. China.ORCID 0000-0002-2496-4053
Shuzhen LiuWeifang People's Hospital, Weifang 261041, P.R. China.
Zhen CaiFuwai Hospital Chinese Academy of Medical Sciences, Shenzhen, Shenzhen 518000, Guangdong Province, P.R. China.
Jieyu WuDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm 171 77, Sweden.ORCID 0000-0002-7063-6990
Jiaqi ZhaoDepartment of Hepatobiliary and Pancreatic Surgery, Shenzhen People's Hospital, The First Affiliated Hospital of Southern University of Science and Technology, Shenzhen 518020, Guangdong, P.R. China.ORCID 0000-0002-9446-5225
Zongze WuDepartment of Hepatobiliary and Pancreatic Surgery, Shenzhen People's Hospital, The First Affiliated Hospital of Southern University of Science and Technology, Shenzhen 518020, Guangdong, P.R. China.
Yuhua ZhangDepartment of Hepatobiliary and Pancreatic Surgery, Shenzhen People's Hospital, The First Affiliated Hospital of Southern University of Science and Technology, Shenzhen 518020, Guangdong, P.R. China.
Chaoying WeiDepartment of Hepatobiliary and Pancreatic Surgery, Shenzhen People's Hospital, The First Affiliated Hospital of Southern University of Science and Technology, Shenzhen 518020, Guangdong, P.R. China.
Qiaoting YanDepartment of Hepatobiliary and Pancreatic Surgery, Shenzhen People's Hospital, The First Affiliated Hospital of Southern University of Science and Technology, Shenzhen 518020, Guangdong, P.R. China.
Hongzhong WangDepartment of Hepatobiliary and Pancreatic Surgery, Shenzhen People's Hospital, The First Affiliated Hospital of Southern University of Science and Technology, Shenzhen 518020, Guangdong, P.R. China.
Dianyuan FanShenzhen Engineering Laboratory of Phosphorene and Optoelectronics, International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of Education, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, P.R. China.
Liping LiuDepartment of Hepatobiliary and Pancreatic Surgery, Shenzhen People's Hospital, The First Affiliated Hospital of Southern University of Science and Technology, Shenzhen 518020, Guangdong, P.R. China.ORCID 0000-0003-2616-5973
Han ZhangShenzhen Engineering Laboratory of Phosphorene and Optoelectronics, International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of Education, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, P.R. China.ORCID 0000-0002-0166-1973
Yihai CaoDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm 171 77, Sweden.ORCID 0000-0003-1308-0065

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Two-dimensional nanomaterial-based photothermal therapy (PTT) is currently under intensive investigation as a promising approach toward curative cancer treatment. However, high toxicity, moderate efficacy, and low uniformity in shape remain critical unresolved issues that hamper their clinical application. Thus, there is an urgent need for developing versatile nanomaterials to meet clinical expectations. To achieve this goal, we developed a stable, highly uniform in size, and nontoxic nanomaterials made of tellurium-selenium (TeSe)-based lateral heterojunction. Systemic delivery of TeSe nanoparticles in mice showed highly specific accumulation in tumors relative to other healthy tissues. Upon exposure to light, TeSe nanoparticles nearly completely eradicated lung cancer and hepatocellular carcinoma in preclinical models. Consistent with tumor suppression, PTT altered the tumor microenvironment and induced immense cancer cell apoptosis. Together, our findings demonstrate an exciting and promising PTT-based approach for cancer eradication.

Indexed as

Drug CarriersMetal NanoparticlesSeleniumTelluriumAnimalsAntineoplastic AgentsBiomarkersCell Line, TumorChemical PhenomenaDisease Models, AnimalFluorescent Antibody TechniqueHumansMiceXenograft Model Antitumor AssaysAntineoplastic AgentsBiomarkersDrug CarriersSeleniumTellurium

Identifiers

PMID32284997
PMCPMC7141822

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.