ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2020
Extensive memory testing improves prediction of progression to MCI in late middle age.
Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 22 citations in OpenAlex.
- Young adult urbanicity, late midlife neighborhood disadvantage, and cognitive functioning in community-dwelling older men.The journals of gerontology. Series B, Psychological sciences and social sciences · 2026Article
- Subjective memory concern, negative affect, and cortical microstructural integrity in community-dwelling middle-aged men.GeroScience · 2026Article
- Practice effects persist over two decades of cognitive testing: Implications for longitudinal research.medRxiv : the preprint server for health sciences · 2025Article
- Development and validation of an episodic memory measure in the Mobile Toolbox (MTB): Arranging Pictures.Journal of clinical and experimental neuropsychology · 2024Article
- Associations of plasma neurofilament light chain with cognition and neuroimaging measures in community-dwelling early old age men.Alzheimer's research & therapy · 2024Article
- Association Between Traumatic Brain Injury and Cognitive Decline Among Middle-to-Older Aged Men in the Vietnam Era Twin Study of Aging.Neurotrauma reports · 2024Article
- Exploring the Impact of Age of Onset of Mild Cognitive Impairment on the Profile of Cognitive and Psychiatric Symptoms.Geriatrics (Basel, Switzerland) · 2023Article
- Alzheimer's Disease Polygenic Scores Predict Changes in Episodic Memory and Executive Function Across 12 Years in Late Middle Age.Journal of the International Neuropsychological Society : JINS · 2023Article
- Associations Between Ambient Air Pollution and Cognitive Abilities from Midlife to Early Old Age: Modification by APOE Genotype.Journal of Alzheimer's disease : JAD · 2023Article
- Memory markers in the continuum of the Alzheimer's clinical syndrome.Alzheimer's research & therapy · 2022Article
- Cognitive practice effects delay diagnosis of MCI: Implications for clinical trials.Alzheimer's & dementia (New York, N. Y.) · 2022Article
- MRI-assessed locus coeruleus integrity is heritable and associated with multiple cognitive domains, mild cognitive impairment, and daytime dysfunction.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2021Article
- Psychometric Evaluation and Workflow Integration Study of a Tablet-Based Tool to Detect Mild Cognitive Impairment in Older Adults: Protocol for a Mixed Methods Study.JMIR research protocols · 2021Article
- How Well Does Subjective Cognitive Decline Correspond to Objectively Measured Cognitive Decline? Assessment of 10-12 Year Change.Journal of Alzheimer's disease : JAD · 2021Article
- Subtle cognitive impairment as a marker of Alzheimer's pathologies and clinical progression in cognitively normal individuals.Alzheimer's & dementia (Amsterdam, Netherlands) · 2021Article
- Cognitive Practice Effects Delay Diagnosis; Implications for Clinical Trials.medRxiv : the preprint server for health sciences · 2020Article
- Degree of cognitive impairment does not signify early versus late mild cognitive impairment: confirmation based on Alzheimer's disease polygenic risk.Neurobiology of aging · 2020Article
- Amyloid-β Positivity Predicts Cognitive Decline but Cognition Predicts Progression to Amyloid-β Positivity.Biological psychiatry · 2020Article
- Extensive memory testing improves prediction of progression to MCI in late middle age.Alzheimer's & dementia (Amsterdam, Netherlands) · 2020Article
- Relationships among young adult general cognitive ability, midlife physical activity, and early late-life cognitive functioning: A four-decade longitudinal cohort study in men.Alzheimer's & dementia (Amsterdam, Netherlands)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
introductionPredicting risk for Alzheimer's disease when most people are likely still biomarker negative would aid earlier identification. We hypothesized that combining multiple memory tests and scores in middle-aged adults would provide useful, and non-invasive, prediction of 6-year progression to MCI.
methodsWe examined 849 men who were cognitively normal at baseline (mean age ± SD = 55.69 ± 2.45).
resultsCalifornia Verbal Learning Test learning trials was the best individual predictor of amnestic MCI (OR = 4.75). A latent factor incorporating seven measures across three memory tests provided much stronger prediction (OR = 9.88). This compared favorably with biomarker-based prediction in a study of much older adults. DISCUSSION: Neuropsychological tests are sensitive and early indicators of MCI risk at an age when few individuals are likely to have yet become biomarker positive. The single best measures may appear time- and cost-effective, but 30 additional minutes of testing and use of multiple scores within tests provide substantially improved prediction.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.