ArticleBasic and clinical neuroscience
Curcumin Effects on Memory Impairment and Restoration of Irregular Neuronal Distribution in the Hippocampal CA1 Region After Global Cerebral Ischemia in Male Rats.
Article in Basic and clinical neuroscience. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 22 citations in OpenAlex.
- Effect of acute and chronic stress on memory impairment and hippocampal oxidative stress following global cerebral ischemia in adult male rats.Research in pharmaceutical sciences · 2024Article
- The effect of curcumin on blood pressure and cognitive impairment in spontaneously hypertensive rats.Nutrition research and practice · 2023Article
- Mechanisms Underlying Curcumin-Induced Neuroprotection in Cerebral Ischemia.Frontiers in pharmacology · 2022Review
- Electroacupuncture Promotes the Survival of the Grafted Human MGE Neural Progenitors in Rats with Cerebral Ischemia by Promoting Angiogenesis and Inhibiting Inflammation.Neural plasticity · 2021Article
- Progress in Natural Compounds/siRNA Co-delivery Employing Nanovehicles for Cancer Therapy.ACS combinatorial science · 2020Review
- Age-dependent changes in the medial prefrontal cortex and medial amygdala structure, and elevated plus-maze performance in the healthy male Wistar rats.IBRO reports · 2020Article
- Curcumin prevents neuronal loss and structural changes in the superior cervical (sympathetic) ganglion induced by chronic sleep deprivation, in the rat model.Biological research · 2020Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionGlobal Cerebral Ischemia (GCI) causes neuronal damage with subsequent neurological and cognitive impairments. Curcumin has anti-inflammatory, antioxidant, and neuroprotective properties, which makes it a potential candidate for improving GCI-induced impairments. This study aimed to investigate the effects of curcumin on the neurological and memory deficits, as well as spatial neuronal distribution in the Cornu Ammonis 1 region after GCI in rats.
methods56 Sprague-Dawley male rats were randomly assigned into 4 groups of sham (n=14), control (n=14), curcumin 50 mg/kg (n=14), and curcumin 100 mg/kg (n=14). Each group was divided into the two subgroups of short-term (7 days) and long-term (28 days) treatment periods. The Neurological Severity Score (NSS), passive avoidance task, and the traction test were performed at postoperative days of 0, 1, 2, 3, 7, 14, 21, and 28. The novel object recognition test and Voronoi tessellation were carried out on days 7 and 28 after GCI.
resultsCurcumin 100 mg/kg significantly decreased neurological severity score on postoperative days of 7 and 28 compared with the control (P<0.001) and curcumin 50 mg/kg groups (P<0.05-P<0.001),
conclusionCurcumin could improve memory and neurological deficits and restore irregular neuronal distribution in the CA1 region after GCI in a time-dependent manner, and its higher dose was more effective than its lower dose. Curcumin may have beneficial effects on reducing brain complications after ischemia.
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