Evidence map›Paper›PMID 32284789›Full record

ArticleOncotarget2020

Investigation of the role of VHL-HIF signaling in DNA repair and apoptosis in zebrafish.

Hyejeong Rosemary Kim, Kirankumar Santhakumar, Eleanor Markham, Davide Baldera, David Greenald, Helen E Bryant, Sherif F El-Khamisy, Fredericus J van Eeden

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Zebrafish Cancer Predisposition Models.Frontiers in cell and developmental biology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Hyejeong Rosemary KimBateson Centre/BMS, Firth Court, University of Sheffield, Sheffield S10 2TN, UK.
Kirankumar SanthakumarDepartment of Genetic Engineering, SRM Institute of Science and Technology, Kattankulathur 603203, India.
Eleanor MarkhamBateson Centre/BMS, Firth Court, University of Sheffield, Sheffield S10 2TN, UK.
Davide BalderaBateson Centre/BMS, Firth Court, University of Sheffield, Sheffield S10 2TN, UK.
David GreenaldCentre for Discovery Brain Sciences, University of Edinburgh, Chancellor's Building, Edinburgh EH16 4SB, UK.
Helen E BryantDepartment of Oncology & Metabolism, The Medical School, Sheffield S10 2RX, UK.
Sherif F El-KhamisyDepartment of Molecular Biology and Biotechnology, Firth Court, University of Sheffield, Sheffield S10 2TN, UK.
Fredericus J van EedenBateson Centre/BMS, Firth Court, University of Sheffield, Sheffield S10 2TN, UK.
University of Sheffield · GBSRM Institute of Science and Technology · INUniversity of Edinburgh · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

pVHL is a tumor suppressor. The lack of its function leads to various tumors, among which ccRCC (clear cell renal cell carcinoma) has the most serious outcome due to its resistance to chemotherapies and radiotherapies. Although HIF promotes the progression of ccRCC, the precise mechanism by which the loss of VHL leads to tumor initiation remains unclear. We exploited two zebrafish

Indexed as

apoptosischemo/radio-resistanceDNA repairHifVhl

Identifiers

PMID32284789
PMCPMC7138166
OpenAlexW3016022344

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.