Evidence map›Paper›PMID 32284773›Full record

ArticleWorld journal of oncology2020

Esophageal Cancer: An Updated Surveillance Epidemiology and End Results Database Analysis.

Eric Omar Then, Michell Lopez, Saad Saleem, Vijay Gayam, Tagore Sunkara, Andrea Culliford, Vinaya Gaduputi

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 199 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
199citing papers in PubMed, 10 pooled it
34.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

199 citing papers in PubMed, 10 syntheses or guidelines pooled it, 307 citations in OpenAlex.

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  14. Inaccessible mental health care is a risk factor for risky drinking behaviors among cancer survivors: an All of Us survey-based cohort study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
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  20. Speaking Volumes About High-Volume Centers.Annals of surgical oncology · 2026
    Article

139 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Eric Omar ThenDivision of Gastroenterology and Hepatology, SBH Health System, 4422 Third Ave, Bronx, NY 10457, USA.
Michell LopezDivision of Gastroenterology and Hepatology, SBH Health System, 4422 Third Ave, Bronx, NY 10457, USA.
Saad SaleemDepartment of Internal Medicine, Mercy Saint Vincent Medical Center, 2213 Cherry St, Toledo, OH 43608, USA.
Vijay GayamDepartment of Internal Medicine, Interfaith Medical Center, 1545 Atlantic Ave, Brooklyn, NY 11213, USA.
Tagore SunkaraDivision of Gastroenterology and Hepatology, Mercy Medical Center, 1111 6th Ave, Des Moines, IA 50314, USA.
Andrea CullifordDivision of Gastroenterology and Hepatology, SBH Health System, 4422 Third Ave, Bronx, NY 10457, USA.
Vinaya GaduputiDivision of Gastroenterology and Hepatology, SBH Health System, 4422 Third Ave, Bronx, NY 10457, USA.
Montefiore Health System · USNorthwell Health · USInterfaith Medical Center · USMercy Medical Center · USMercy St. Vincent Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEsophageal cancer is the sixth leading cause of cancer-related deaths and the eighth most common cancer worldwide with a 5-year survival rate of less than 25%. Here we report the incidence, risk factors and treatment options that are available currently, and moving into the future.

methodsWe retrospectively analyzed the Surveillance Epidemiology and End Results (SEER) database made available by the National Cancer Institute in the USA. Specifically we extracted data from the years 2004 - 2015.

resultsIn total we identified 23,804 patients with esophageal adenocarcinoma and 13,919 patients with esophageal squamous cell carcinoma. Males were at an increased risk of developing both types of esophageal cancer when compared to females. Most cases of adenocarcinoma were diagnosed as poorly differentiated grade III (42%), and most cases of squamous cell carcinoma were diagnosed as moderately differentiated grade II (39.5%). The most common stage of presentation for both adenocarcinoma (36.9%) and squamous cell (26.8%) carcinoma was stage IV. The worst outcomes for adenocarcinoma were noted with grade III tumors (hazard ratio (HR): 1.56, 95% confidence interval (CI): 1.44 - 1.68, P value: < 0.01), stage IV tumors (HR: 3.58, 95% CI: 3.33 - 3.85, P value: < 0.01) and those not treated with surgery (HR: 2.54, 95% CI: 2.44 - 2.65, P value: < 0.01). For squamous cell carcinoma, the worst outcomes were noted with grade III tumors (HR: 1.35, 95% CI: 1.23 - 1.49, P value: < 0.01), stage IV tumors (HR: 2.12, 95% CI: 1.94 - 2.32, P value: <0.01).

conclusionsThe incidence of esophageal adenocarcinoma in the USA is steadily on the rise. Conversely, the incidence of squamous cell carcinoma has been continually declining. While white males had an increased incidence of both types of esophageal cancer, a higher proportion of African Americans suffered from squamous cell carcinoma. Despite the wide spread use of proton pump inhibitors, adenocarcinoma continues to be a major public health concern.

Indexed as

AdenocarcinomaChemotherapyEsophageal cancerRadiotherapySquamous cell carcinoma

Identifiers

PMID32284773
PMCPMC7141161
OpenAlexW3013311028

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.