ArticleNature neuroscience2020
Four core properties of the human brain valuation system demonstrated in intracranial signals.
Article in Nature neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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Who cites it
54 citing papers in PubMed, 117 citations in OpenAlex.
- An amygdala-mediated simulation-to-decision cascade aligns interbrain dynamics to solve social dilemmas.Nature neuroscience · 2026Article
- Electrophysiological dissociation of human posterior cingulate cortex contributions to value- and memory-based decision-making.bioRxiv : the preprint server for biology · 2026Article
- Complementary and opponent value signals in the human brain support choosing the best and avoiding the worst.Nature communications · 2026Article
- Closed-loop readout of anterior insula high-gamma activity steers value-based decisions.Nature communications · 2026Article
- Neural basis of attitude change motivated by cognitive dissonance: a scoping review.Cognitive, affective & behavioral neuroscience · 2026Article
- Joint effect of uncertainty-of-outcome and calorie content on food preference.Scientific reports · 2026Article
- Complex functions of human lateral frontopolar cortex.Brain : a journal of neurology · 2025Review
- Reward circuit local field potential modulations precede risk taking.Brain : a journal of neurology · 2025Article
- Largely Intact But Less Reliable and Distributed Neural Representations of Subjective Value in Human Opioid Addiction.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Subjective valuation as a domain-general process in creative thinking.Communications psychology · 2025Article
- Orbitofrontal High-Gamma Reflects Spike-Dissociable Value and Decision Mechanisms.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Distributed Intracranial Activity Underlying Human Decision-making Behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- The human reward system encodes the subjective value of ideas during creative thinking.Communications biology · 2025Article
- Representation of Anticipated Rewards and Punishments in the Human Brain.Annual review of psychology · 2025Review
- Simultaneous intracranial recordings of interacting brains reveal neurocognitive dynamics of human cooperation.Nature neuroscience · 2025Article
- Article
- Reward recalibrates rule representations in human amygdala and hippocampus intracranial recordings.Nature communications · 2024Article
- Decision-making shapes dynamic inter-areal communication within macaque ventral frontal cortex.Current biology : CB · 2024Article
- Direct stimulation of anterior insula and ventromedial prefrontal cortex disrupts economic choices.Nature communications · 2024Article
- Intracranial EEG signals disentangle multi-areal neural dynamics of vicarious pain perception.Nature communications · 2024Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Estimating the value of alternative options is a key process in decision-making. Human functional magnetic resonance imaging and monkey electrophysiology studies have identified brain regions, such as the ventromedial prefrontal cortex (vmPFC) and lateral orbitofrontal cortex (lOFC), composing a value system. In the present study, in an effort to bridge across species and techniques, we investigated the neural representation of value ratings in 36 people with epilepsy, using intracranial electroencephalography. We found that subjective value was positively reflected in both vmPFC and lOFC high-frequency activity, plus several other brain regions, including the hippocampus. We then demonstrated that subjective value could be decoded (1) in pre-stimulus activity, (2) for various categories of items, (3) even during a distractive task and (4) as both linear and quadratic signals (encoding both value and confidence). Thus, our findings specify key functional properties of neural value signals (anticipation, generality, automaticity, quadraticity), which might provide insights into human irrational choice behaviors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.