Evidence map›Paper›PMID 32284593›Full record

ArticleNature immunology2020

Eomes identifies thymic precursors of self-specific memory-phenotype CD8

Christine H Miller, David E J Klawon, Sharon Zeng, Victoria Lee, Nicholas D Socci, Peter A Savage

Open access · greenAbstract read
In one paragraph

Article in Nature immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 85 citations in OpenAlex.

  1. Article
  2. Article
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  7. Article
  8. Features of Peripheral T Cell Remigration into the Thymus.International journal of molecular sciences · 2025
    Review
  9. Article
  10. Article
  11. UFL1 promotes survival and function of virtual memory CD8 T cells.Journal of immunology (Baltimore, Md. : 1950) · 2025
    Article
  12. Review
  13. Epigenetics behind CD8Genes and immunity · 2024
    Review
  14. Article
  15. Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Christine H MillerDepartment of Pathology, University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0003-2176-9516
David E J KlawonDepartment of Pathology, University of Chicago, Chicago, IL, USA.
Sharon ZengDepartment of Pathology, University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0001-7150-1345
Victoria LeeDepartment of Pathology, University of Chicago, Chicago, IL, USA.
Nicholas D SocciBioinformatics Core, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Peter A SavageDepartment of Pathology, University of Chicago, Chicago, IL, USA. psavage@bsd.uchicago.edu.ORCID http://orcid.org/0000-0002-2506-7717
University of Chicago · USMemorial Sloan Kettering Cancer Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
MEDICAL SCIENTIST TRAININGT32GM007281 · NIGMS · UNIVERSITY OF CHICAGO · PI CLARK, MARCUS RAMSAY · 1985 to 2022
$32.1M
INTERDISCIPLINARY TRAINING PROGRAM IN IMMUNOLOGYT32AI007090 · NIAID · UNIVERSITY OF CHICAGO · PI Peter Aidan Savage · 1985 to 2026
$11.7M
Function of Aire-dependent regulatory T cells in immune toleranceR01AI110507 · NIAID · UNIVERSITY OF CHICAGO · PI SAVAGE, PETER AIDAN · 2015 to 2019
$1.7M
Defining tolerance mechanisms regulating self-specific T cellsF30CA217109 · NCI · UNIVERSITY OF CHICAGO · PI LEE, VICTORIA · 2017 to 2021
$250k
Specificity and function of memory-phenotype CD8+ T cells in the tumor environmentF30CA236061 · NCI · UNIVERSITY OF CHICAGO · PI MILLER, CHRISTINE · 2019 to 2022
$203k
NCI NIH HHS F30 CA217109NCI NIH HHS F30 CA236061NCI NIH HHS P30 CA008748NIAID NIH HHS R01 AI110507NIAID NIH HHS T32 AI007090NIGMS NIH HHS T32 GM007281
6 · The paper itself

Abstract

Unprimed mice harbor a substantial population of 'memory-phenotype' CD8

Indexed as

AnimalsAutoantigensCD8-Positive T-LymphocytesCell DifferentiationClonal Selection, Antigen-MediatedClone CellsImmunologic MemoryMaleMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicProgrammed Cell Death 1 ReceptorProstatic NeoplasmsReceptors, Antigen, T-CellT-Box Domain ProteinsAutoantigensEomes protein, mousePdcd1 protein, mouseProgrammed Cell Death 1 ReceptorReceptors, Antigen, T-CellT-Box Domain Proteins

Identifiers

PMID32284593
PMCPMC7193531
OpenAlexW3015265202

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.