Evidence map›Paper›PMID 32284589›Full record

ArticleNature medicine2020

Adaptive evolution of virulence and persistence in carbapenem-resistant Klebsiella pneumoniae.

Christoph M Ernst, Julian R Braxton, Carlos A Rodriguez-Osorio, Anna P Zagieboylo, Li Li, Alejandro Pironti, Abigail L Manson, Anil V Nair, Maura Benson, Kaelyn Cummins and 4 more

Erratum issuedOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 215 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
215citing papers in PubMed, 2 pooled it
10.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

215 citing papers in PubMed, 2 syntheses or guidelines pooled it, 299 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. ElevatedEmerging microbes & infections · 2026
    Article
  5. Article
  6. Article
  7. Within-patient carbapenem heteroresistance inCurrent research in microbial sciences · 2026
    Article
  8. Article
  9. Article
  10. Carbapenemase-producingEmerging microbes & infections · 2026
    Article
  11. Article
  12. The Manipulation of Host Cells byInternational journal of molecular sciences · 2026
    Review
  13. Review
  14. Hypermucoviscosity inJournal of bacteriology · 2026
    Review
  15. Biofilm-Mediated Antimicrobial Resistance in PediatricAntibiotics (Basel, Switzerland) · 2026
    Review
  16. mBio · 2026
    Article
  17. Article
  18. Article
  19. TARGETING THE CAPSULE OFbioRxiv : the preprint server for biology · 2026
    Article
  20. Article

155 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Christoph M ErnstThe Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-5575-1325
Julian R Braxton *The Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-1170-5140
Carlos A Rodriguez-Osorio *The Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-4972-4611
Anna P Zagieboylo *The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Li LiThe Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Alejandro PirontiThe Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-7759-6776
Abigail L MansonThe Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Anil V NairCenter for Systems Biology, Program in Membrane Biology, Division of Nephrology, Massachusetts General Hospital, Boston, MA, USA.
Maura BensonDivision of Infectious Diseases, Brigham and Women's Hospital, Boston, MA, USA.
Kaelyn CumminsDivision of Infectious Diseases, Brigham and Women's Hospital, Boston, MA, USA.
Anne E ClatworthyThe Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Ashlee M EarlThe Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-7857-9145
Lisa A CosimiDivision of Infectious Diseases, Brigham and Women's Hospital, Boston, MA, USA.
Deborah T HungThe Broad Institute of MIT and Harvard, Cambridge, MA, USA. hung@molbio.mgh.harvard.edu.ORCID http://orcid.org/0000-0003-4262-0673
Broad Institute · USBrigham and Women's Hospital · USMassachusetts General Hospital · US

Funding

Viral Genomics: evolution, spread, and host interactionsU19AI110818 · NIAID · BROAD INSTITUTE, INC. · PI EARL, ASHLEE MIRIAM · 2014 to 2024
$66.5M
Pilot & Feasibility ProgramP30DK043351 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI RAYMOND T CHUNG · 1991 to 2026
$35.3M
Transgenic CoreP30DK057521 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI KAHN, BARBARA B. · 2000 to 2019
$31.4M
RNA based diagnostics for rapid pathogen identification and drug resistanceR01AI117043 · NIAID · BROAD INSTITUTE, INC. · PI HUNG, DEBORAH T · 2015 to 2019
$6.5M
A Zeiss LSM800 confocal microscope with AiryscanS10OD021577 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI BROWN, DENNIS · 2016 to 2016
$374k
NIAID NIH HHS R01 AI117043NIAID NIH HHS U19 AI110818NIDDK NIH HHS P30 DK043351NIDDK NIH HHS P30 DK057521NIH HHS S10 OD021577
6 · The paper itself

Abstract

Among the most urgent public health threats is the worldwide emergence of carbapenem-resistant Enterobacteriaceae

Indexed as

Evolution, MolecularAdaptation, BiologicalAdultAnimalsBacterial Capsulesbeta-Lactam ResistanceCarbapenem-Resistant EnterobacteriaceaeCarbapenemsCells, CulturedFemaleGenome, BacterialHumansKlebsiella InfectionsKlebsiella pneumoniaeMiceMice, Inbred BALB CCarbapenems

Identifiers

PMID32284589
PMCPMC9194776
OpenAlexW3015496474

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.