Evidence map›Paper›PMID 32284513›Full record

ArticleInternational journal of molecular sciences2020

Cell-Penetrating Peptides Enhance the Activity of Human Fibroblast Growth Factor 2 by Prolonging the Retention Time: A New Vision for Drug-Delivery Systems.

Jaehoon Lee, Mijin Kwon, Naeun Oh, Jaehyun Park, Sangkyu Park, Jeongmin Seo, Sangho Roh

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 9 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Jaehoon LeeBiomedical Research Institute, NeoRegen Biotech Co., Ltd., Gyeonggi-do 16614, Korea.
Mijin KwonCellular Reprogramming and Embryo Biotechnology Laboratory, Dental Research Institute, Seoul National University School of Dentistry, Seoul 08826, Korea.
Naeun OhCellular Reprogramming and Embryo Biotechnology Laboratory, Dental Research Institute, Seoul National University School of Dentistry, Seoul 08826, Korea.
Jaehyun ParkCellular Reprogramming and Embryo Biotechnology Laboratory, Dental Research Institute, Seoul National University School of Dentistry, Seoul 08826, Korea.
Sangkyu ParkBiomedical Research Institute, NeoRegen Biotech Co., Ltd., Gyeonggi-do 16614, Korea.
Jeongmin SeoBiomedical Research Institute, NeoRegen Biotech Co., Ltd., Gyeonggi-do 16614, Korea.
Sangho RohCellular Reprogramming and Embryo Biotechnology Laboratory, Dental Research Institute, Seoul National University School of Dentistry, Seoul 08826, Korea.ORCID 0000-0001-8082-6459
Seoul National University · KR

Funding

Gyeonggi Province D191972Ministry of SMEs and Startups S2519744
6 · The paper itself

Abstract

Cell-penetrating peptides (CPPs) are defined by their ability to deliver cargo into cells and have been studied and developed as a promising drug-delivery system (DDS). However, the issue of whether the CPPs that have already entered the cells can be re-released or reused has not been studied. The purpose of this research was to construct CPP-conjugated human fibroblast growth factor 2 (hFGF2) and investigate whether they can be re-released from the cell membrane for reuse. This study combined hFGF2 with Tat or Ara27, a newly developed CPP derived from the zinc knuckle (CCHC-type) family protein of

Indexed as

Drug Delivery SystemsArabidopsisCell MembraneCell-Penetrating PeptidesEndocytosisFibroblast Growth Factor 2HumansCell-Penetrating PeptidesFibroblast Growth Factor 2Ara27cell-penetrating peptidesdrug-delivery systemfibroblast growth factor 2re-release

Identifiers

PMID32284513
PMCPMC7013552
OpenAlexW3000231695

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.