ArticleProceedings of the National Academy of Sciences of the United States of America2020
Curling of epithelial monolayers reveals coupling between active bending and tissue tension.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Dynamic interactions between epithelial skin cells and a sensory cavity sculpt the growing olfactory orifice.Nature communications · 2026Article
- Quantitative imaging of corneal endothelial development reveals dynamic but resilient monolayer.bioRxiv : the preprint server for biology · 2026Article
- Cilia-driven epithelial folding and unfolding in an early diverging animal.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Shaping 3D minimal model tissues with mechanical constraints to orchestrate muscle differentiation.Communications biology · 2025Article
- Tissue tension of planar, free standing cell monolayers measured by central deformation.PNAS nexus · 2025Article
- Mechanics of pressurized cellular sheets.Journal of the Royal Society, Interface · 2025Article
- Mechanochemical bistability of intestinal organoids enables robust morphogenesis.Nature physics · 2025Article
- Rupture strength of living cell monolayers.Nature materials · 2024Article
- Mapping mechanical stress in curved epithelia of designed size and shape.Nature communications · 2023Article
- A novel tool for the unbiased characterization of epithelial monolayer development in culture.Molecular biology of the cell · 2023Article
- Actomyosin contractility in olfactory placode neurons opens the skin epithelium to form the zebrafish nostril.Developmental cell · 2023Article
- Article
- Mechanical stress driven by rigidity sensing governs epithelial stability.Nature physics · 2023Article
- How dynamic prestress governs the shape of living systems, from the subcellular to tissue scale.Interface focus · 2022Review
- Tension at intercellular junctions is necessary for accurate orientation of cell division in the epithelium plane.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Collective curvature sensing and fluidity in three-dimensional multicellular systems.Nature physics · 2022Article
- Bioengineered 3D Tissue Model of Intestine Epithelium with Oxygen Gradients to Sustain Human Gut Microbiome.Advanced healthcare materials · 2022Article
- Collective motion of epithelial cells along a wrinkled 3D-buckled hydrogel.RSC advances · 2022Article
- Thickness of epithelia on wavy substrates: measurements and continuous models.The European physical journal. E, Soft matter · 2022Article
- Computer modeling reveals modalities to actuate mutable, active matter.Nature communications · 2022Article
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Authors and funding
9 authors.
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Abstract
Epithelial monolayers are two-dimensional cell sheets which compartmentalize the body and organs of multicellular organisms. Their morphogenesis during development or pathology results from patterned endogenous and exogenous forces and their interplay with tissue mechanical properties. In particular, bending of epithelia is thought to result from active torques generated by the polarization of myosin motors along their apicobasal axis. However, the contribution of these out-of-plane forces to morphogenesis remains challenging to evaluate because of the lack of direct mechanical measurement. Here we use epithelial curling to characterize the out-of-plane mechanics of epithelial monolayers. We find that curls of high curvature form spontaneously at the free edge of epithelial monolayers devoid of substrate in vivo and in vitro. Curling originates from an enrichment of myosin in the basal domain that generates an active spontaneous curvature. By measuring the force necessary to flatten curls, we can then estimate the active torques and the bending modulus of the tissue. Finally, we show that the extent of curling is controlled by the interplay between in-plane and out-of-plane stresses in the monolayer. Such mechanical coupling emphasizes a possible role for in-plane stresses in shaping epithelia during morphogenesis.
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