Evidence map›Paper›PMID 32284374›Full record

ArticleInfection and immunity2020

Salmonella enterica Infection of Murine and Human Enteroid-Derived Monolayers Elicits Differential Activation of Epithelium-Intrinsic Inflammasomes.

Mayumi K Holly, Xiao Han, Edward J Zhao, Shauna M Crowley, Joannie M Allaire, Leigh A Knodler, Bruce A Vallance, Jason G Smith

Open access · greenAbstract read
In one paragraph

Article in Infection and immunity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 57 citations in OpenAlex.

  1. Article
  2. Article
  3. An overview of human inflammasomes: Activation and regulation.Journal of immunology (Baltimore, Md. : 1950) · 2026
    Review
  4. Article
  5. Differential targeting of human pyroptotic Caspase-5 and Caspase-4 bybioRxiv : the preprint server for biology · 2025
    Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Inflammasomes primarily restrict cytosolicbioRxiv : the preprint server for biology · 2024
    Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Mayumi K Holly *Department of Microbiology, University of Washington School of Medicine, Seattle, Washington, USA.ORCID 0000-0003-4717-1088
Xiao Han *Division of Gastroenterology, Department of Pediatrics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada.
Edward J ZhaoDepartment of Biostatistics, University of Washington School of Public Health, Seattle, Washington, USA.
Shauna M CrowleyDivision of Gastroenterology, Department of Pediatrics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada.
Joannie M AllaireDivision of Gastroenterology, Department of Pediatrics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada.
Leigh A Knodler *Paul G. Allen School for Global Animal Health, College of Veterinary Medicine, Washington State University, Pullman, Washington, USA.ORCID 0000-0002-3028-2198
Bruce A Vallance *Division of Gastroenterology, Department of Pediatrics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada bvallance@cw.bc.ca jgsmith2@uw.edu.ORCID 0000-0003-1345-6747
Jason G Smith *Department of Microbiology, University of Washington School of Medicine, Seattle, Washington, USA bvallance@cw.bc.ca jgsmith2@uw.edu.ORCID 0000-0001-6727-5269
University of British Columbia · CAUniversity of Washington · USWashington State University · US

Funding

TRAINING IN MOLECULAR AND CELLULAR BIOLOGYT32GM007270 · NIGMS · UNIVERSITY OF WASHINGTON · PI RAIBLE, DAVID W · 1985 to 2020
$21.0M
Anti-viral Mechanisms of DefensinsR01AI104920 · NIAID · UNIVERSITY OF WASHINGTON · PI MCKENNA, ROBERT, SMITH, JASON G · 2014 to 2023
$6.1M
Predoctoral Research Training in Statistical Genetics Administrative SupplementT32GM081062 · NIGMS · UNIVERSITY OF WASHINGTON · PI THORNTON, TIMOTHY ALVIN · 2007 to 2021
$2.4M
Epithelial intrinsic inflammasomes direct host defense against gut microbesR01AI134766 · NIAID · WASHINGTON STATE UNIVERSITY · PI KNODLER, LEIGH · 2018 to 2022
$2.2M
Azure Sapphire BioimagerS10OD026741 · OD · UNIVERSITY OF WASHINGTON · PI SMITH, JASON G · 2019 to 2019
$76k
CIHRNIAID NIH HHS R01 AI104920NIAID NIH HHS R01 AI134766NIGMS NIH HHS T32 GM007270NIGMS NIH HHS T32 GM081062NIH HHS S10 OD026741
6 · The paper itself

Abstract

Recent studies have determined that inflammasome signaling plays an important role in driving intestinal epithelial cell (IEC) responses to bacterial infections, such as

Indexed as

AnimalsBiomarkersCaspasesCell LineCytokinesDisease Models, AnimalGene ExpressionHumansInflammasomesIntestinal MucosaMiceSalmonella entericaSalmonella InfectionsBiomarkersCaspasesCytokinesInflammasomescaspasesenteroidinflammasomeSalmonella

Identifiers

PMID32284374
PMCPMC7309616
OpenAlexW3015451581

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.