Functional Properties of Helicobacter pylori VacA Toxin m1 and m2 Variants.
Rhonda R Caston, Johanna C Sierra, Nora J Foegeding, Mandy D Truelock, Anne M Campbell, Arwen E Frick-Cheng, Diane Bimczok, Keith T Wilson, Mark S McClain, Timothy L Cover
Article in Infection and immunity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
15 citing papers in PubMed, 16 citations in OpenAlex.
Microbiology and molecular biology reviews : MMBR · 2026
Genome ofInternational journal of environmental research and public health · 2021
Article
4 · The record
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
10 authors at 2 institutions in 1 country.
Rhonda R CastonDepartment of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Johanna C SierraDepartment of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Nora J FoegedingDepartment of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Mandy D TruelockDepartment of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Anne M CampbellDepartment of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Arwen E Frick-ChengDepartment of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Diane BimczokDepartment of Microbiology and Immunology, Montana State University, Bozeman, Montana, USA.
Keith T WilsonDepartment of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Mark S McClainDepartment of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.ORCID 0000-0002-9857-4883
Timothy L CoverDepartment of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA timothy.l.cover@vumc.org.ORCID 0000-0001-8503-002X
Vanderbilt University · USMontana State University · US
Funding
Research Core (Developmental Research Project Program)P20GM103474 · NIGMS · MONTANA STATE UNIVERSITY - BOZEMAN · PI Jeffrey Good · 2012 to 2026
$60.0M
Translational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2002 to 2026
$29.9M
Role of Iron and B-Catenin Activation in Gastric CarcinogenesisP01CA116087 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Kevin L Schey · 2009 to 2026
$27.5M
Project 3 - Molecular Signatures of Gastric Carcinogenesis in the Host Response to H. pyloriP01CA028842 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI WILSON, KEITH T. · 1985 to 2019
$15.8M
Structure-function analysis of H. pylori VacAR01AI039657 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI TIMOTHY L COVER · 1996 to 2026
$8.3M
Type IV Protein Secretion in Helicobacter pyloriR01AI118932 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI COVER, TIMOTHY L, OHI, MELANIE DIANE · 2016 to 2025
$6.7M
Using the GoFlowChip to understand SARS-CoV-2 infection of the gastrointestinal mucosa of humans and batsU01EB029242 · NIBIB · MONTANA STATE UNIVERSITY - BOZEMAN · PI BIMCZOK, DIANE, WALK, SETH T · 2019 to 2023
$4.0M
MOLECULAR PARASITOLOGY TRAINING PROGRAMT32AI007281 · NIAID · MEHARRY MEDICAL COLLEGE · PI NDE, PIUS N · 1985 to 2025
$3.2M
Targeted chemoprevention of gastric carcinogenesis in high risk populationsR01CA190612 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MORGAN, DOUGLAS, WILSON, KEITH T. · 2014 to 2018
$3.0M
LSM880-Airyscan Confocal Microscope for Large Shared ResourceS10OD021630 · OD · VANDERBILT UNIVERSITY · PI WELLS, K. SAM · 2016 to 2016
$560k
The Macrophage Reverse Transsulfuration Pathway: A Novel Mediator of Helicobacter pylori ImmunopathogenesisR21AI142042 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI WILSON, KEITH T. · 2019 to 2020
$468k
Harnessing human gastric organoids to investigate the role of CD103 in gastric dendritic cell – epithelial cell crosstalkR03DK107960 · NIDDK · MONTANA STATE UNIVERSITY - BOZEMAN · PI BIMCZOK, DIANE · 2015 to 2016
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Functional Properties of Helicobacter pylori VacA Toxin m1 and m2 Variants. · full record | OpenQuestion