Evidence map›Paper›PMID 32284366›Full record

ArticleInfection and immunity2020

Aging Dampens the Intestinal Innate Immune Response during Severe Clostridioides difficile Infection and Is Associated with Altered Cytokine Levels and Granulocyte Mobilization.

Lisa Abernathy-Close, Michael G Dieterle, Kimberly C Vendrov, Ingrid L Bergin, Krishna Rao, Vincent B Young

Open access · greenAbstract read
In one paragraph

Article in Infection and immunity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.3field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Global Patterns ofCrohn's & colitis 360 · 2025
    Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Lisa Abernathy-Close *Division of Infectious Diseases, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0002-6543-7014
Michael G Dieterle *Medical Scientist Training Program, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0002-3109-6151
Kimberly C VendrovDivision of Infectious Diseases, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0002-9131-5272
Ingrid L BerginUnit for Laboratory Animal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Krishna RaoDivision of Infectious Diseases, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0002-9213-7850
Vincent B YoungDivision of Infectious Diseases, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA youngvi@umich.edu.ORCID 0000-0003-3687-2364
University of Michigan · US

Funding

MICHIGAN MEDICAL SCIENTIST TRAINING PROGRAMT32GM007863 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI COLLINS, KATHLEEN L. · 1985 to 2024
$38.3M
Systems biology of Clostridium difficile infectionU01AI124255 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SCHLOSS, PATRICK DAVID, YOUNG, VINCENT B · 2016 to 2020
$9.8M
Training in Basic and Translational Digestive SciencesT32DK094775 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI JOHN Y KAO, LINDA C. SAMUELSON · 2012 to 2026
$3.6M
NIAID NIH HHS U01 AI124255NIDDK NIH HHS T32 DK094775NIGMS NIH HHS T32 GM007863
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Immunity, InnateAgingAnimalsChemotaxis, LeukocyteClostridioides difficileClostridium InfectionsCytokinesEosinophilsGranulocytesHost-Pathogen InteractionsImmunity, CellularImmunophenotypingIntestinesMiceNeutrophilsCytokinesagingClostridioides difficileeosinophilsgastrointestinal infectioninnate immunityintestinal colonization

Identifiers

PMID32284366
PMCPMC7240091
OpenAlexW3016200641

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.