Evidence map›Paper›PMID 32284330›Full record

ArticleThe Journal of biological chemistry2020

Transient kinetic analysis of oxidative dealkylation by the direct reversal DNA repair enzyme AlkB.

Michael R Baldwin, Suzanne J Admiraal, Patrick J O'Brien

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Spectroscopic and in vitro Investigations of FeChembiochem : a European journal of chemical biology · 2022
    Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Michael R BaldwinDepartment of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan 48109-0600.
Suzanne J AdmiraalDepartment of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan 48109-0600.
Patrick J O'BrienDepartment of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan 48109-0600. Electronic address: pjobrien@umich.edu.
University of Michigan · US

Funding

XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Alexey I Nesvizhskii · 1988 to 2026
$178.2M
NCI NIH HHS P30 CA046592
6 · The paper itself

Abstract

AlkB is a bacterial Fe(II)- and 2-oxoglutarate-dependent dioxygenase that repairs a wide range of alkylated nucleobases in DNA and RNA as part of the adaptive response to exogenous nucleic acid-alkylating agents. Although there has been longstanding interest in the structure and specificity of

Indexed as

DNA RepairAlkB EnzymesAlkB Homolog 2, Alpha-Ketoglutarate-Dependent DioxygenaseAlkB Homolog 3, Alpha-Ketoglutarate-Dependent DioxygenaseDNADNA, BacterialDNA, Single-StrandedEscherichia coliEscherichia coli ProteinsHumansAlkB EnzymesALKBH2 protein, humanALKBH3 protein, humanAlkB Homolog 2, Alpha-Ketoglutarate-Dependent DioxygenaseAlkB Homolog 3, Alpha-Ketoglutarate-Dependent DioxygenaseDNADNA, BacterialDNA, Single-StrandedEscherichia coli Proteinsadaptive responseAlkAAlkBALKBHDNA adductDNA damageDNA repairEscherichia coli (E. coli)oxidative dealkylationpre-steady-state kineticssubstrate specificity

Identifiers

PMID32284330
PMCPMC7247310
OpenAlexW3015730796

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.