Evidence map›Paper›PMID 32283875›Full record

ReviewNutrients2020

Breast Milk, a Source of Beneficial Microbes and Associated Benefits for Infant Health.

Katríona E Lyons, C Anthony Ryan, Eugene M Dempsey, R Paul Ross, Catherine Stanton

2 registry-linked trialsOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 285 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
285citing papers in PubMed, 11 pooled it
37.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05803577 unknown statusnot on this mapstarted 2021, after this paper: background citation

Preterm Infants: Microbiome Establishment, Neuro Cross-talk, and Origins

TypeobservationalSponsorUniversity College CorkRan2021 to 2025Enrolled91ConditionsPrematurity, Microbial Colonization
NCT06303232 nacompletednot on this mapstarted 2023, after this paper: background citation

Combined Effects of Manual Lymphatic Drainage and Therapeutic Ultrasound on Breast Engorgement, Pain and Self Efficacy in Postpartum Women

TypeinterventionalSponsorRiphah International UniversityRan2023 to 2024Enrolled42ConditionsPostpartum ComplicationArmsMANUAL LYMPHATIC DRAINAGE, THERAPEUTIC ULTRASOUND
3 · Its place in the literature

Who cites it

285 citing papers in PubMed, 11 syntheses or guidelines pooled it, 573 citations in OpenAlex.

  1. Pooled it
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  3. Guideline
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  12. Trial
  13. Effects of maternal allergy and supplementation with ω-3 fatty acid and probiotic on human milk oligosaccharides.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2025
    Trial
  14. Trial
  15. Biomarker-based text messages to promote lactation success in mothers of critically Ill infants: a randomized controlled pilot study.Journal of perinatology : official journal of the California Perinatal Association · 2024
    Trial
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  18. Article
  19. Review
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225 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Katríona E LyonsTeagasc Food Research Centre, Moorepark, Fermoy, Co. Cork P61 C996, Ireland.
C Anthony RyanAPC Microbiome Ireland, University College Cork, Cork T12 YT20, Ireland.
Eugene M DempseyAPC Microbiome Ireland, University College Cork, Cork T12 YT20, Ireland.
R Paul RossAPC Microbiome Ireland, University College Cork, Cork T12 YT20, Ireland.
Catherine StantonTeagasc Food Research Centre, Moorepark, Fermoy, Co. Cork P61 C996, Ireland.
APC Microbiome Institute · IEInfant · IETeagasc - The Irish Agriculture and Food Development Authority · IEUniversity College Cork · IE

Funding

Department of Agriculture, Food and the Marine 15F721
6 · The paper itself

Abstract

Human breast milk is considered the optimum feeding regime for newborn infants due to its ability to provide complete nutrition and many bioactive health factors. Breast feeding is associated with improved infant health and immune development, less incidences of gastrointestinal disease and lower mortality rates than formula fed infants. As well as providing fundamental nutrients to the growing infant, breast milk is a source of commensal bacteria which further enhance infant health by preventing pathogen adhesion and promoting gut colonisation of beneficial microbes. While breast milk was initially considered a sterile fluid and microbes isolated were considered contaminants, it is now widely accepted that breast milk is home to its own unique microbiome. The origins of bacteria in breast milk have been subject to much debate, however, the possibility of an entero-mammary pathway allowing for transfer of microbes from maternal gut to the mammary gland is one potential pathway. Human milk derived strains can be regarded as potential probiotics; therefore, many studies have focused on isolating strains from milk for subsequent use in infant health and nutrition markets. This review aims to discuss mammary gland development in preparation for lactation as well as explore the microbial composition and origins of the human milk microbiota with a focus on probiotic development.

Indexed as

Breast FeedingInfant HealthProbioticsFemaleGastrointestinal DiseasesGastrointestinal MicrobiomeHumansInfantInfant, NewbornInfant Nutritional Physiological PhenomenaMaleMilk, Humanbreast milkentero-mammary pathwayhuman milk oligosaccharides (HMOs), human milk microbiomelactationmammary glandprobiotic

Identifiers

PMID32283875
PMCPMC7231147
OpenAlexW3015536860

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.