ArticleMolecules (Basel, Switzerland)2020
Enhancing the Membranolytic Activity of
Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 30 citations in OpenAlex.
- Article
- Saponins Do Not Impede the Bioaccessibility of Minerals and Fat-Soluble Vitamins from Different Quinoa Genotypes.Journal of agricultural and food chemistry · 2026Article
- Analytical Methods for Identification and Quantification of Quinoa Saponins: A Review.ACS omega · 2026Review
- Structural Characterization and Profiles of Saponins from Two Algerian Sea Cucumbers.Molecules (Basel, Switzerland) · 2024Article
- Flavonoid glycosides fromHeliyon · 2024Article
- Review
- Combination of Fenugreek and Quinoa Husk as Sources of Steroidal and Triterpenoid Saponins: Bioactivity of Their Co-Extracts and Hydrolysates.Foods (Basel, Switzerland) · 2024Article
- Optimization of green deep eutectic solvent (DES) extraction ofRSC advances · 2023Article
- Horse Chestnut Saponins-Escins, Isoescins, Transescins, and Desacylescins.Molecules (Basel, Switzerland) · 2023Article
- Botanicals: A promising approach for controlling cecal coccidiosis in poultry.Frontiers in veterinary science · 2023Review
- Harnessing the Role of Bacterial Plasma Membrane Modifications for the Development of Sustainable Membranotropic Phytotherapeutics.Membranes · 2022Review
- Comparative Study of Three Dyes' Adsorption onto Activated Carbon fromMaterials (Basel, Switzerland) · 2022Article
- Microwave-Assisted Acid Hydrolysis vs. Conventional Hydrolysis to Produce Sapogenin-Rich Products from Fenugreek Extracts.Foods (Basel, Switzerland) · 2022Article
- Impact of the Hydrolysis and Methanolysis of BidesmosidicMolecules (Basel, Switzerland) · 2022Article
- Microwave-Assisted Desulfation of the Hemolytic Saponins Extracted fromMolecules (Basel, Switzerland) · 2022Article
- Lipid Flip-Flop-Inducing Antimicrobial Phytochemicals fromACS omega · 2021Article
- Microwave technology: a novel approach to the transformation of natural metabolites.Chinese medicine · 2021Review
- Editorial to Special Issue-"Structure-Activity Relationships (SAR) of Natural Products".Molecules (Basel, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Saponins are plant secondary metabolites. There are associated with defensive roles due to their cytotoxicity and are active against microorganisms. Saponins are frequently targeted to develop efficient drugs. Plant biomass containing saponins deserves sustained interest to develop high-added value applications. A key issue when considering the use of saponins for human healthcare is their toxicity that must be modulated before envisaging any biomedical application. This can only go through understanding the saponin-membrane interactions. Quinoa is abundantly consumed worldwide, but the quinoa husk is discarded due to its astringent taste associated with its saponin content. Here, we focus on the saponins of the quinoa husk extract (QE). We qualitatively and quantitively characterized the QE saponins using mass spectrometry. They are bidesmosidic molecules, with two oligosaccharidic chains appended on the aglycone with two different linkages; a glycosidic bond and an ester function. The latter can be hydrolyzed to prepare monodesmosidic molecules. The microwave-assisted hydrolysis reaction was optimized to produce monodesmosidic saponins. The membranolytic activity of the saponins was assayed based on their hemolytic activity that was shown to be drastically increased upon hydrolysis. In silico investigations confirmed that the monodesmosidic saponins interact preferentially with a model phospholipid bilayer, explaining the measured increased hemolytic activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.