Evidence map›Paper›PMID 32283751›Full record

ArticleMolecules (Basel, Switzerland)2020

Theoretical Studies Aimed at Finding FLT3 Inhibitors and a Promising Compound and Molecular Pattern with Dual Aurora B/FLT3 Activity.

Ítalo Antônio Fernandes, Déborah Braga Resende, Teodorico Castro Ramalho, Kamil Kuca, Elaine Fontes Ferreira da Cunha

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Ítalo Antônio FernandesDepartment of Chemistry, Federal University of Lavras, P.O. Box 3037, Lavras-MG 37200-000, Brazil.
Déborah Braga ResendeDepartment of Veterinary Medicine, Federal University of Lavras, P.O. Box 3037, Lavras-MG 37200-000, Brazil.
Teodorico Castro RamalhoDepartment of Chemistry, Federal University of Lavras, P.O. Box 3037, Lavras-MG 37200-000, Brazil.ORCID 0000-0002-7324-1353
Kamil KucaFaculty of Science, Department of Chemistry, University of Hradec Kralove, Rokitanskeho 62, 500 03 Hradec Kralove, Czech Republic.ORCID 0000-0001-9664-1109
Elaine Fontes Ferreira da CunhaDepartment of Chemistry, Federal University of Lavras, P.O. Box 3037, Lavras-MG 37200-000, Brazil.
Universidade Federal de Lavras · BRUniversity of Hradec Králové · CZ

Funding

CNPq CAPESUHK Excellence project
6 · The paper itself

Abstract

FLT3 and dual Aurora B/FLT3 inhibitors have shown relevance in the search for promising new anticancer compounds, mainly for acute myeloid leukemia (AML). This study was designed to investigate the interactions between human FLT3 in the kinase domain with several indolin-2-one derivatives, structurally similar to Sunitinib. Molegro Virtual Docker (MVD) software was utilized in docking analyses. The predicted model of the training group, considering nineteen amino acid residues, performed in Chemoface, achieved an R

Indexed as

Models, TheoreticalAlgorithmsAurora Kinase BEnzyme Activationfms-Like Tyrosine Kinase 3HumansInhibitory Concentration 50Models, MolecularMolecular ConformationMolecular StructureProtein Kinase InhibitorsStructure-Activity RelationshipAURKB protein, humanAurora Kinase BFLT3 protein, humanfms-Like Tyrosine Kinase 3Protein Kinase Inhibitorscomputational chemistrydual Aurora B/FLT3 inhibitorsindolin−2-one derivatives

Identifiers

PMID32283751
PMCPMC7181172
OpenAlexW3016114544

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.