Evidence map›Paper›PMID 32283597›Full record

ArticleAntibiotics (Basel, Switzerland)2020

Impact of Antimicrobial Stewardship Interventions on Appropriateness of Surgical Antibiotic Prophylaxis: How to Improve.

Beatrice Tiri, Paolo Bruzzone, Giulia Priante, Emanuela Sensi, Monya Costantini, Carlo Vernelli, Lucia Assunta Martella, Marsilio Francucci, Paolo Andreani, Alessandro Mariottini and 5 more

Abstract read
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Beatrice TiriAntimicrobial Stewardship Unit, Department of medicine, St. Maria Hospital, 05100 Terni; Italy.ORCID 0000-0001-5574-7812
Paolo BruzzoneDepartment of General and Specialist Surgery "Paride Stefanini", 00100 Rome, Italy.ORCID 0000-0002-7124-1245
Giulia PrianteInfectious Diseases Clinic, Department of medicine, St. Maria Hospital, 05100 Terni, Italy.
Emanuela SensiDepartment of Critical Care Medicine and Anesthesiology, St. Maria Hospital, 05100 Terni, Italy.
Monya CostantiniPharmacy Unit, St. Maria Hospital, 05100 Terni, Italy.
Carlo VernelliInfectious Diseases Clinic, Department of medicine, St. Maria Hospital, 05100 Terni, Italy.
Lucia Assunta MartellaInfectious Diseases Clinic, Department of medicine, St. Maria Hospital, 05100 Terni, Italy.
Marsilio FrancucciDepartment of General and Oncologic Surgery, St. Maria Hospital, 05100 Terni, Italy.
Paolo AndreaniHematology and Microbiology Laboratory, St. Maria Hospital, 05100 Terni, Italy.
Alessandro MariottiniHematology and Microbiology Laboratory, St. Maria Hospital, 05100 Terni, Italy.
Andrea CapotortiDepartment of Mathematics and Informatics, University of Perugia, 06121 Perugia, Italy.ORCID 0000-0002-1337-8315
Vito D'AndreaDepartment of Surgical Sciences, Sapienza University of Rome, 00100 Rome, Italy.ORCID 0000-0001-5709-2530
Daniela FrancisciDepartment of Medicine, University of Perugia, 06121 Perugia, Italy.
Roberto CirocchiDepartment of Surgical Sciences, University of Perugia, 06121 Perugia, Italy.ORCID 0000-0002-2457-0636
Stefano CappaneraAntimicrobial Stewardship Unit, Department of medicine, St. Maria Hospital, 05100 Terni; Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Surgical site infections (SSIs) are the most common healthcare-associated infections. The appropriate use of Surgical Antibiotic Prophylaxis (SAP) is a key component to reduce SSIs, while its inappropriate application is a major cause of some emerging infections and selects for antibiotic resistance. We describe an Antimicrobial Stewardship (AMS) intervention on SAP appropriateness. The prospective study was conducted in an Italian hospital, in 12 main surgical units, and was organized in three subsequent phases, as follows. Phase 0: Definition of hospital evidence-based guidelines and a new workflow to optimize the process of ordering, dispensing, administering and documenting the SAP. Phase 1: We analysed 2059 elective surgical cases from January to June 2018 for three SAP parameters of appropriateness: indication, choice and dose. Phase 2: In July 2018, an audit was performed to analyse the results; we reviewed 1781 elective surgical procedures from July to December 2018 looking for the same three SAP appropriateness parameters. The comparative analysis between phases 1 and 2 demonstrated that the correct indication, the correct dose and the overall compliance significantly improved (

Indexed as

antibiotic resistanceantimicrobial stewardshipappropriatenesshealthcare-associated infectionssurgical antibiotic prophylaxissurgical site infections

Identifiers

PMID32283597
PMCPMC7235845

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.