Evidence map›Paper›PMID 32283495›Full record

ArticleDNA repair2020

Cross-linking of the DNA repair protein O

Xun Ming, Erin D Michaelson-Richie, Arnold S Groehler, Peter W Villalta, Colin Campbell, Natalia Y Tretyakova

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in DNA repair, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Xun MingDepartment of Medicinal Chemistry and the Masonic Cancer Center, University of Minnesota, Minneapolis, MN, 55455, USA.
Erin D Michaelson-RichieDepartment of Medicinal Chemistry and the Masonic Cancer Center, University of Minnesota, Minneapolis, MN, 55455, USA.
Arnold S GroehlerCenter for Genomic Integrity, Institute for Basic Science, Ulsan, Republic of Korea.
Peter W VillaltaMass Spectrometry Core at the Masonic Cancer Center, University of Minnesota, Minneapolis, MN, 55455, USA.
Colin CampbellDepartment of Pharmacology, University of Minnesota, Minneapolis, MN, 55455, USA.
Natalia Y TretyakovaDepartment of Medicinal Chemistry and the Masonic Cancer Center, University of Minnesota, Minneapolis, MN, 55455, USA. Electronic address: trety001@umn.edu.
University of Minnesota · USInstitute for Basic Science · KR

Funding

DNA Protein Cross-Links:Cellular Effects and Repair MechanismsR01ES023350 · NIEHS · UNIVERSITY OF MINNESOTA · PI CAMPBELL, COLIN R, TRETYAKOVA, NATALIA Y · 2014 to 2023
$5.0M
Chemistry-Biology Interface Training GrantT32GM008700 · NIGMS · UNIVERSITY OF MINNESOTA TWIN CITIES · PI DISTEFANO, MARK D · 1999 to 2018
$4.0M
DNA Cross-Linking By DiepoxybutaneR01CA100670 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI TRETYAKOVA, NATALIA Y · 2003 to 2021
$3.5M
NCI NIH HHS R01 CA100670NIEHS NIH HHS R01 ES023350NIGMS NIH HHS T32 GM008700
6 · The paper itself

Abstract

1,1,2,2-cis-diamminedichloroplatinum (II) (cisplatin) is a chemotherapeutic agent widely used in the clinic to treat various cancers. The antitumor activity of cisplatin is generally attributed to its ability to form intrastrand and interstrand DNA-DNA cross-links via sequential platination of two nucleophilic sites within the DNA duplex. However, cisplatin also induces DNA- protein lesions (DPCs) that may contribute to its biological effects due to their ability to block DNA replication and transcription. We previously reported that over 250 nuclear proteins including high mobility group proteins, histone proteins, and elongation factors formed DPCs in human HT1080 cells treated with cisplatin (Ming et al. Chem. Res. Toxicol. 2017, 30, 980-995). Interestingly, cisplatin-induced DNA-protein conjugates were reversed upon heating, by an unknown mechanism. In the present work, DNA repair protein O

Indexed as

DNA AdductsModels, MolecularAntineoplastic AgentsChromatography, High Pressure LiquidCisplatinCross-Linking ReagentsDNAHumansO(6)-Methylguanine-DNA MethyltransferaseProtein ConformationRecombinant ProteinsSequence Analysis, ProteinTandem Mass SpectrometryAntineoplastic AgentsCisplatinCross-Linking ReagentsDNADNA AdductsO(6)-Methylguanine-DNA MethyltransferaseRecombinant ProteinsAGTCisplatinDNA-protein cross-linksMass spectrometry

Identifiers

PMID32283495
PMCPMC8177102
OpenAlexW3011575918

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.