Evidence map›Paper›PMID 32283325›Full record

ArticleClinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association2020

Clinical Features of COVID-19-Related Liver Functional Abnormality.

Zhenyu Fan, Liping Chen, Jun Li, Xin Cheng, Jingmao Yang, Cheng Tian, Yajun Zhang, Shaoping Huang, Zhanju Liu, Jilin Cheng

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04669509 (Effect of Liver Injury on Mortality in Coronavirus Disease-2019 Patients Admitted to Intensive Care Unit), which is not on this map. Cited by 517 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
517citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04669509 completednot on this map

Effect of Liver Injury on Mortality in Coronavirus Disease-2019 Patients Admitted to Intensive Care Unit

TypeobservationalSponsorSaglik Bilimleri Universitesi Gazi Yasargil Training and Research HospitalRan2020 to 2020Enrolled532ConditionsCovid19, Liver Injury, MortalityArmsLiver function tests
3 · Its place in the literature

Who cites it

517 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
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  14. COVID-19 Infection, Drugs, and Liver Injury.Journal of clinical medicine · 2025
    Review
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  18. Liver Function Abnormalities in Patients withInfection and drug resistance · 2025
    Article
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457 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Zhenyu FanDepartment of Gastroenterology and Hepatology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Liping ChenDepartment of Gastroenterology and Hepatology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Jun LiDepartment of Gastroenterology and Hepatology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Xin ChengDepartment of Gastroenterology and Hepatology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Jingmao YangDepartment of Gastroenterology and Hepatology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Cheng TianDepartment of Gastroenterology and Hepatology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Yajun ZhangDepartment of Gastroenterology and Hepatology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Shaoping HuangDepartment of Gastroenterology and Hepatology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Zhanju LiuDepartment of Gastroenterology, The Shanghai Tenth People's Hospital of Tongji University, Shanghai, China. Electronic address: liuzhanju88@126.com.
Jilin ChengDepartment of Gastroenterology and Hepatology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China. Electronic address: chengjilin@shphc.org.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND &

aimsSome patients with SARS-CoV-2 infection have abnormal liver function. We aimed to clarify the features of COVID-19-related liver damage to provide references for clinical treatment.

methodsWe performed a retrospective, single-center study of 148 consecutive patients with confirmed COVID-19 (73 female, 75 male; mean age, 50 years) at the Shanghai Public Health Clinical Center from January 20 through January 31, 2020. Patient outcomes were followed until February 19, 2020. Patients were analyzed for clinical features, laboratory parameters (including liver function tests), medications, and length of hospital stay. Abnormal liver function was defined as increased levels of alanine and aspartate aminotransferase, gamma glutamyltransferase, alkaline phosphatase, and total bilirubin.

resultsFifty-five patients (37.2%) had abnormal liver function at hospital admission; 14.5% of these patients had high fever (14.5%), compared with 4.3% of patients with normal liver function (P = .027). Patients with abnormal liver function were more likely to be male, and had higher levels of procalcitonin and C-reactive protein. There was no statistical difference between groups in medications taken before hospitalization; a significantly higher proportion of patients with abnormal liver function (57.8%) had received lopinavir/ritonavir after admission compared to patients with normal liver function (31.3%). Patients with abnormal liver function had longer mean hospital stays (15.09 ± 4.79 days) than patients with normal liver function (12.76 ± 4.14 days) (P = .021).

conclusionsMore than one third of patients admitted to the hospital with SARS-CoV-2 infection have abnormal liver function, and this is associated with longer hospital stay. A significantly higher proportion of patients with abnormal liver function had received lopinavir/ritonavir after admission; these drugs should be given with caution.

Indexed as

Liver Function TestsAdultAntiviral AgentsBetacoronavirusBilirubinBlood Chemical AnalysisChinaCoronavirus InfectionsCOVID-19EnzymesFemaleHospitalsHumansLiver DiseasesLopinavirMaleAntiviral AgentsBilirubinEnzymesLopinavirRitonavirALPAntiviral DrugLiver InjuryPrognosis

Identifiers

PMID32283325
PMCPMC7194865

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.