ArticleNeuroscience2020
Hedonic Eating: Sex Differences and Characterization of Orexin Activation and Signaling.
Article in Neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 47 citations in OpenAlex.
- Trial
- The Neural Network of Orexin-A: Implications in Feeding Regulation and Obesity-Anxiety Comorbidity.Brain sciences · 2026Review
- Sex and age effects on binge eating spectrum disorders in young adults: a path analysis.Frontiers in psychology · 2026Article
- Adolescent and adult age differences in palatable food learning and consumption.Physiology & behavior · 2025Article
- Impact of satiety on palatable food associative learning and consumption in male and female adult rats.Physiology & behavior · 2025Article
- The rostromedial tegmental nucleus gates fat overconsumption through ventral tegmental area output in male rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Review
- AgRP neuron activity promotes associations between sensory and nutritive signals to guide flavor preference.Molecular metabolism · 2023Article
- The metabolic effects of resumption of a high fat diet after weight loss are sex dependent in mice.Scientific reports · 2023Article
- Sex Differences in Behavior and Learning Abilities in Adult Rats.Life (Basel, Switzerland) · 2023Article
- Association Between Food Intake and Gastrointestinal Symptoms in Patients With Obesity.Gastro hep advances · 2023Article
- Orexin and MCH neurons: regulators of sleep and metabolism.Frontiers in neuroscience · 2023Review
- Habitual behaviour associated with exposure to high-calorie diet is prevented by an orexin-receptor-1 antagonist.Addiction neuroscience · 2022Article
- Sex differences in activation of extra-hypothalamic forebrain areas during hedonic eating.Brain structure & function · 2022Article
- Conceptualization of Rice with Low Glycaemic Index: Perspectives from the Major European Consumers.Foods (Basel, Switzerland) · 2022Article
- Appetitive Behavior in the Social Transmission of Food Preference Paradigm Predicts Activation of Orexin-A producing Neurons in a Sex-Dependent Manner.Neuroscience · 2022Article
- Activation of Hypocretin Neurons in Endometriosis.Reproductive sciences (Thousand Oaks, Calif.) · 2022Article
- Role of Nociceptin/Orphanin FQ-NOP Receptor System in the Regulation of Stress-Related Disorders.International journal of molecular sciences · 2021Review
- A Narrative Review of Sex Differences in Eating Disorders: Is There a Biological Basis?Clinical therapeutics · 2021Review
- Sex Differences in Metabolic Recuperation After Weight Loss in High Fat Diet-Induced Obese Mice.Frontiers in endocrinology · 2021Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Palatable taste can stimulate appetite in the absence of hunger, and individual differences in hedonic eating may be critical to overeating. Women are more prone to obesity and binge eating than men, which warrants comparisons of hedonic versus physiological consumption and the underlying neural substrates in both sexes. The current study examined palatable (high-sugar) food consumption in male and female rats under physiological hunger and satiety, and the role of the neuropeptide orexin/hypocretin (ORX). Across multiple tests, females consistently consumed similar amounts of palatable food regardless of whether they were hungry or sated prior to testing. In contrast, males typically adjusted their consumption according to their hunger/satiety state. This difference was specific to palatable food consumption, as both sexes ate standard chow according to their hunger state. ORX is important in food motivation and reward behaviors. Thus, to begin to determine the neuronal mechanisms of hedonic eating, we examined activation and signaling of ORX neurons. We systematically characterized Fos induction patterns of ORX neurons across the entire rostrocaudal extent of the lateral hypothalamus and found that they were activated by food and by fasting in both sexes. Then, we showed that systemic blockade of ORX receptor 1 signaling with SB-334867 decreased palatable food consumption in hungry and sated rats of both sexes. These results demonstrate sex differences in hedonic eating; increased susceptibility in females to overeat palatable food regardless of hunger state, and that ORX is a critical neuropeptide mechanism of hedonic eating in both sexes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.