Evidence map›Paper›PMID 32283006›Full record

ArticleACS chemical neuroscience2020

SARS-CoV-2: Olfaction, Brain Infection, and the Urgent Need for Clinical Samples Allowing Earlier Virus Detection.

Rafal Butowt, Katarzyna Bilinska

Registry-linked trialOpen access · bronzeAbstract read
PubMed Publisher
In one paragraph

Article in ACS chemical neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04894409 (Evaluation of Silver Nanoparticles as an Oropharyngeal Product), which is not on this map. Cited by 207 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
207citing papers in PubMed, 5 pooled it
25.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04894409 nacompletednot on this map

Evaluation of Silver Nanoparticles as an Oropharyngeal Product (Mouthwash) and Nasal Hygiene, by Health Personnel Working at the Tijuana General Hospital Exposed to Patients Diagnosed With Atypical Pneumonia Caused by SARS-CoV-2

TypeinterventionalSponsorCluster de Bioeconomia de Baja California, A.CRan2020 to 2020Enrolled231ConditionsCoronavirus Disease 2019 (COVID-19)ArmsMouthwash and nose rinse with the AgNPs solution, Mouthwashes and nose rinse in a conventional way
3 · Its place in the literature

Who cites it

207 citing papers in PubMed, 5 syntheses or guidelines pooled it, 359 citations in OpenAlex.

  1. Pooled it
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  4. Consensus statement. Corticosteroid therapy in ENT in the context of the COVID-19 pandemic.European annals of otorhinolaryngology, head and neck diseases · 2020
    Guideline
  5. Pooled it
  6. Trial
  7. Trial
  8. Review
  9. Article
  10. Article
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  13. A pediatric case of central diabetes insipidus and hypopituitarism after COVID-19 suspected with lymphocytic hypophysitis with positive anti-rabphilin-3A antibodies.Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology · 2026
    Article
  14. Article
  15. Article
  16. Review
  17. Subjective and objective effects of radioiodine therapy on the sense of smell.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024
    Article
  18. Article
  19. Review
  20. Article

147 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Rafal ButowtL. Rydygier Collegium Medicum, Nicolaus Copernicus University, Ul. CurieSklodowskiej 9, 85-94 Bydgoszcz, Poland.
Katarzyna BilinskaL. Rydygier Collegium Medicum, Nicolaus Copernicus University, Ul. CurieSklodowskiej 9, 85-94 Bydgoszcz, Poland.
Nicolaus Copernicus University · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The novel SARS-CoV-2 virus has very high infectivity, which allows it to spread rapidly around the world. Attempts at slowing the pandemic at this stage depend on the number and quality of diagnostic tests performed. We propose that the olfactory epithelium from the nasal cavity may be a more appropriate tissue for detection of SARS-CoV-2 virus at the earliest stages, prior to onset of symptoms or even in asymptomatic people, as compared to commonly used sputum or nasopharyngeal swabs. Here we emphasize that the nasal cavity olfactory epithelium is the likely site of enhanced binding of SARS-CoV-2. Multiple non-neuronal cell types present in the olfactory epithelium express two host receptors, ACE2 and TMPRSS2 proteases, that facilitate SARS-CoV-2 binding, replication, and accumulation. This may be the underlying mechanism for the recently reported cases of smell dysfunction in patients with COVID-19. Moreover, the possibility of subsequent brain infection should be considered which begins in olfactory neurons. In addition, we discuss the possibility that olfactory receptor neurons may initiate rapid immune responses at early stages of the disease. We emphasize the need to undertake research focused on additional aspects of SARS-CoV-2 actions in the nervous system, especially in the olfactory pathway.

Indexed as

Early DiagnosisSmellAngiotensin-Converting Enzyme 2AnimalsBetacoronavirusBrainCoronavirus InfectionsCOVID-19HumansImmunity, InnateMass ScreeningMiceOlfactory MucosaOlfactory Receptor NeuronsPandemicsPeptidyl-Dipeptidase AACE2 protein, humanAce2 protein, mouseAngiotensin-Converting Enzyme 2Peptidyl-Dipeptidase ASerine EndopeptidasesTMPRSS2 protein, humanACE2 expressionCOVID-19olfactory epitheliumrespiratory epitheliumSARS-CoV-2TMPRSS2 expressionviral brain infection

Identifiers

PMID32283006
OpenAlexW3015599845

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.