ArticleThe Plant journal : for cell and molecular biology2020
The foxtail millet (Setaria italica) terpene synthase gene family.
Article in The Plant journal : for cell and molecular biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25 citing papers in PubMed, 48 citations in OpenAlex.
- Discovery of the rosalexin pathway expands the modular network of maize diterpenoid phytoalexins.Research square · 2026Article
- A Review of Plant-Derived Diterpenoid Biosynthesis: From Structural Scaffold Diversity and Lineage-Associated Distribution to Enzyme Mining and Discovery Strategies.Molecules (Basel, Switzerland) · 2026Review
- Identification of photosynthetic pigment content-related genes in peanut (Arachis hypogaea L.) by GWAS and RNA-seq.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Discovery of Coracanols A and B, Two Biological Nitrification Inhibition Diterpenoids from Finger Millet.Organic letters · 2026Article
- Jasmonates regulate drought resistance by controlling the secondary metabolism in wheat seedlings.BMC plant biology · 2026Article
- Genome-wide analysis of terpene synthase family in peanut (Arachis hypogaea L.) explores the potential cross-talk in terpenoid biosynthesis.BMC genomics · 2025Article
- Characterization of switchgrass (Panicum virgatum L.) PvKSL1 as a levopimaradiene/abietadiene-type diterpene synthase.Plant biology (Stuttgart, Germany) · 2025Article
- Discovery and characterisation of terpenoid biosynthesis enzymes from Daphniphyllum macropodum.BMC plant biology · 2025Article
- Cloning and functional identification of sesquiterpene synthase geneFrontiers in plant science · 2025Article
- Genome-wide identification and expression analyses ofPhysiology and molecular biology of plants : an international journal of functional plant biology · 2024Article
- Pangenome Identification and Analysis of Terpene Synthase Gene Family Members inInternational journal of molecular sciences · 2024Article
- Enhancing structural diversity of terpenoids by multisubstrate terpene synthases.Beilstein journal of organic chemistry · 2024Review
- Influences of Jujube Witches' Broom (JWB) Phytoplasma Infection and Oxytetracycline Hydrochloride Treatment on the Gene Expression Profiling in Jujube.International journal of molecular sciences · 2023Article
- Genome-wide identification and expression analysis of terpene synthases in Gossypium species in response to gossypol biosynthesis.Functional & integrative genomics · 2023Article
- In Silico Genome-Wide Mining and Analysis of Terpene Synthase Gene Family in Hevea Brasiliensis.Biochemical genetics · 2023Article
- Stressing the importance of plant specialized metabolites: omics-based approaches for discovering specialized metabolism in plant stress responses.Frontiers in plant science · 2023Review
- Systematic identification of TPS genes in Gossypium and their characteristics in response to flooding stress.Frontiers in plant science · 2023Article
- The chromosome-scale genome of Phoebe bournei reveals contrasting fates of terpene synthase (TPS)-a and TPS-b subfamilies.Plant communications · 2022Article
- Acclimation Strategy of Masson Pine (International journal of molecular sciences · 2022Article
- Genome-wide identification, phylogenetic and expression pattern analysis of MADS-box family genes in foxtail millet (Setaria italica).Scientific reports · 2022Article
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8 authors at 1 institution in 1 country.
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Abstract
Terpenoid metabolism plays vital roles in stress defense and the environmental adaptation of monocot crops. Here, we describe the identification of the terpene synthase (TPS) gene family of the panicoid food and bioenergy model crop foxtail millet (Setaria italica). The diploid S. italica genome contains 32 TPS genes, 17 of which were biochemically characterized in this study. Unlike other thus far investigated grasses, S. italica contains TPSs producing all three ent-, (+)- and syn-copalyl pyrophosphate stereoisomers that naturally occur as central building blocks in the biosynthesis of distinct monocot diterpenoids. Conversion of these intermediates by the promiscuous TPS SiTPS8 yielded different diterpenoid scaffolds. Additionally, a cytochrome P450 monooxygenase (CYP99A17), which genomically clustered with SiTPS8, catalyzes the C19 hydroxylation of SiTPS8 products to generate the corresponding diterpene alcohols. The presence of syntenic orthologs to about 19% of the S. italica TPSs in related grasses supports a common ancestry of selected pathway branches. Among the identified enzyme products, abietadien-19-ol, syn-pimara-7,15-dien-19-ol and germacrene-d-4-ol were detectable in planta, and gene expression analysis of the biosynthetic TPSs showed distinct and, albeit moderately, inducible expression patterns in response to biotic and abiotic stress. In vitro growth-inhibiting activity of abietadien-19-ol and syn-pimara-7,15-dien-19-ol against Fusarium verticillioides and Fusarium subglutinans may indicate pathogen defensive functions, whereas the low antifungal efficacy of tested sesquiterpenoids supports other bioactivities. Together, these findings expand the known chemical space of monocot terpenoid metabolism to enable further investigations of terpenoid-mediated stress resilience in these agriculturally important species.
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