ArticleGenome biology and evolution2020
Distinct Patterns of Selective Sweep and Polygenic Adaptation in Evolve and Resequence Studies.
Article in Genome biology and evolution, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24 citing papers in PubMed, 41 citations in OpenAlex.
- Beyond fixation: persistent genetic variation under intense selection.Molecular biology and evolution · 2026Article
- Beyond Fixation: Persistent Genetic Variation Under Intense Selection.bioRxiv : the preprint server for biology · 2026Article
- Beyond Mendel: a call to revisit the genotype-phenotype map through new experimental paradigms.Genetics · 2026Article
- Genomic Adaptation, Environmental Challenges, and Sustainable Yak Husbandry in High-Altitude Pastoral Systems.Veterinary sciences · 2025Review
- Reduced Parallel Gene Expression Evolution With Increasing Genetic Divergence-A Hallmark of Polygenic Adaptation.Molecular ecology · 2025Article
- Deep learning insights into distinct patterns of polygenic adaptation across human populations.Nucleic acids research · 2024Article
- Article
- Evidence for Admixture and Rapid Evolution During Glacial Climate Change in an Alpine Specialist.Molecular biology and evolution · 2024Article
- Species-specific effects of production practices on genetic diversity in plant reintroduction programs.Evolutionary applications · 2023Article
- Review
- Power of neutrality tests for detecting natural selection.G3 (Bethesda, Md.) · 2023Article
- Artificial selection reveals complex genetic architecture of shoot branching and its response to nitrate supply in Arabidopsis.PLoS genetics · 2023Article
- Embracing Complexity: Yeast Evolution Experiments Featuring Standing Genetic Variation.Journal of molecular evolution · 2023Review
- How predictable is adaptation from standing genetic variation? Experimental evolution inPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Adaptation in Outbred Sexual Yeast is Repeatable, Polygenic and Favors Rare Haplotypes.Molecular biology and evolution · 2022Article
- Genome-wide selection signatures reveal widespread synergistic effects of two different stressors inProceedings. Biological sciences · 2022Article
- Genome-wide signatures of synergistic epistasis during parallel adaptation in a Baltic Sea copepod.Nature communications · 2022Article
- Evolution of γ chain cytokines: Mechanisms, methods and applications.Computational and structural biotechnology journal · 2022Review
- Article
- Ethanol resistance inEcology and evolution · 2021Article
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2 authors.
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Abstract
In molecular population genetics, adaptation is typically thought to occur via selective sweeps, where targets of selection have independent effects on the phenotype and rise to fixation, whereas in quantitative genetics, many loci contribute to the phenotype and subtle frequency changes occur at many loci during polygenic adaptation. The sweep model makes specific predictions about frequency changes of beneficial alleles and many test statistics have been developed to detect such selection signatures. Despite polygenic adaptation is probably the prevalent mode of adaptation, because of the traditional focus on the phenotype, we are lacking a solid understanding of the similarities and differences of selection signatures under the two models. Recent theoretical and empirical studies have shown that both selective sweep and polygenic adaptation models could result in a sweep-like genomic signature; therefore, additional criteria are needed to distinguish the two models. With replicated populations and time series data, experimental evolution studies have the potential to identify the underlying model of adaptation. Using the framework of experimental evolution, we performed computer simulations to study the pattern of selected alleles for two models: 1) adaptation of a trait via independent beneficial mutations that are conditioned for fixation, that is, selective sweep model and 2) trait optimum model (polygenic adaptation), that is adaptation of a quantitative trait under stabilizing selection after a sudden shift in trait optimum. We identify several distinct patterns of selective sweep and trait optimum models in populations of different sizes. These features could provide the foundation for development of quantitative approaches to differentiate the two models.
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